Increasing frequency of Pseudomonas aeruginosa infections during tigecycline use

Journal of Infection in Developing Countries
Aysegul Ulu-KilicHayati Demiraslan

Abstract

The widespread use of tigecycline raises the question of increasing infection rates of Pseudomonas aeruginosa (PA) in ICUs which are not affected by this antibiotic. The aim of this study was to determine if treatment with tigecycline is a risk factor for PA infection in ICU patients. A retrospective and observational study was conducted at Erciyes University Hospital, Turkey, between 2008 and 2010. The Erciyes University Hospital is a 1300-bed tertiary care facility. The patients included in this study were hospitalized in four adult ICUs. Patients with PA infections (case group) were compared with patients with nosocomial infection other than PA (control group). A total of 1,167 patients with any nosocomial infections were included in the study. Two hundred and seventy eight (23.8%) of the patients had PA infection during their ICU stay. Fifty nine patients (21.2%) in the case group received tigecycline before developing PA infections, which were found to be significantly more frequent than in the controls (p < 0.01). Multivariate analysis showed that risk factors for PA infection were previous tigecycline use (4 times), external ventricular shunt (4.2 times), thoracic drainage catheter (2.5 times) and tracheostomy (1.6 times...Continue Reading

Citations

Apr 15, 2016·Journal of Chemotherapy·Maria KatsiariAsimina Maguina
Nov 9, 2018·Frontiers in Genetics·Fernando Sanz-GarcíaJosé L Martínez

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