Increasing hippocampal acetylcholine levels enhance behavioral performance in an animal model of diencephalic amnesia.

Brain Research
Jessica RolandLisa Savage

Abstract

Pyrithiamine-induced thiamine deficiency (PTD) was used to produce a rodent model of Wernicke-Korsakoff syndrome that results in acute neurological disturbances, thalamic lesions, and learning and memory impairments. There is also cholinergic septohippocampal dysfunction in the PTD model. Systemic (Experiment 1) and intrahippocampal (Experiment 2) injections of the acetylcholinesterase inhibitor physostigmine were administered to determine if increasing acetylcholine levels would eliminate the behavioral impairment produced by PTD. Prior to spontaneous alternation testing, rats received injections of either physostigmine (systemic=0.075 mg/kg; intrahippocampal=20, 40 ng/muL) or saline. In Experiment 2, intrahippocampal injections of physostigmine significantly enhanced alternation rates in the PTD-treated rats. In addition, although intrahippocampal infusions of 40 ng of physostigmine increased the available amount of ACh in both pair-fed (PF) and PTD rats, it did so to a greater extent in PF rats. The increase in ACh levels induced by the direct hippocampal application of physostigmine in the PTD model likely increased activation of the extended limbic system, which was dysfunctional, and therefore led to recovery of function ...Continue Reading

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Citations

Jan 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica J RolandKevin C H Pang
Feb 23, 2010·Behavioural Brain Research·Girstautė DagytėAndrea Trentani
Feb 1, 2015·Neuroscience and Biobehavioral Reviews·John C Dalrymple-AlfordMathieu Wolff
Dec 21, 2010·Journal of Ethnopharmacology·M N NasirJ Abdullah
Dec 15, 2010·Pharmacology, Biochemistry, and Behavior·Mark C MoffettLucille A Lumley
Apr 29, 2014·Journal of Molecular Neuroscience : MN·Ieda de Fátima Oliveira-SilvaAngela Maria Ribeiro

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