Increasing hospitalizations due to angioedema in the United States

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Robert Y Lin, Shaili N Shah

Abstract

Angioedema may occur in patients taking angiotensin-converting enzyme inhibitors. With the more prevalent use of this class of medications in the United States, it is not known whether angioedema hospitalizations have increased nationally in recent years. To profile the trends in angioedema hospitalizations and to examine associated demographic factors and comorbid diseases in the United States. A national database of hospitalizations in the United States was queried for hospitalizations with a principal diagnosis of angioedema and other major acute allergic disorders (anaphylaxis, urticaria, and allergy unspecified). Subsequent analysis was performed to determine the current angioedema hospitalization trends (1998-2005) and to examine clinical and demographic variables that distinguished angioedema from the other allergic disease admissions. The angioedema hospitalization rate was 3.3 in 100,000 in 1998 and rose to 4.0 in 100,000 in 2005. In contrast, the combined hospitalization rate for nonangioedema allergic disorders showed an overall decline and was exceeded by angioedema hospitalization rates after 2000. African American patients had consistently higher hospitalization rates (> or = 2 times) for angioedema compared with ...Continue Reading

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