PMID: 7370565Feb 23, 1980Paper

Increasing importance of plasmid-mediated trimethoprim resistance in enterobacteria: two six-month clinical surveys

British Medical Journal
K J TownerF O'Grady

Abstract

All clinical isolates of enterobacteria received at the laboratory were monitored for trimethoprim resistance over six months in 1978. The survey was repeated in 1979 and the incidence of trimethoprim resistance showed a slight decrease, but the proportion of resistant strains owing their trimethoprim resistance to transferable R plasmids had almost trebled. There was also a large increase in the proportion of resistant strains exhibiting high-level non-transferable trimethoprim resistance. These findings suggest transposition of genes conferring trimethoprim resistance from plasmids to the bacterial chromosome.

References

Jun 24, 1978·Lancet·K J TownerF O'Grady
Feb 1, 1978·Journal of Medical Microbiology·R MaskellL Pead
Sep 1, 1978·Journal of Clinical Pathology·S G AmyesJ T Smith
Jan 1, 1979·The Journal of Antimicrobial Chemotherapy·K J TownerF O'Grady
Sep 1, 1977·Journal of General Microbiology·P T Barth, N Datta
May 1, 1974·Journal of Medical Microbiology·R S Jobanputra, N Datta

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Citations

Jan 1, 1988·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J M SmellieN Prescod
Jun 1, 1986·European Journal of Clinical Microbiology·S G AmyesH K Young
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·S G Amyes, H K Young
Jul 1, 1987·Annales De L'Institut Pasteur. Microbiology·S G Amyes
Feb 1, 1987·Epidemiology and Infection·S G Amyes
Jan 7, 1982·The New England Journal of Medicine·G A Jacoby
Apr 1, 1981·Journal of Clinical Pathology·J M Hamilton-MillerW Brumfitt
Aug 30, 1980·British Medical Journal
Sep 1, 1984·Annales de microbiologie·S G Amyes, I M Gould
Jan 1, 1983·Scandinavian Journal of Infectious Diseases·K Dornbusch, A Hagelberg
Jul 1, 1983·Journal of Clinical Microbiology·C H KingM J Dul

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