PMID: 9533726Apr 9, 1998Paper

Increasing incidence of antibiotic resistance in shigellas from humans in England and Wales: recommendations for therapy

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
T CheastyE J Threlfall

Abstract

Since 1983 the incidence of resistance to ampicillin in Shigella dysenteriae, Sh. flexneri, and Sh. boydii infections in England and Wales has increased from 42% to 65% and the incidence of resistance to trimethoprim, from 6% to 64%. Furthermore, of 1524 strains received in 1995-1996, 46% were resistant to both of these antimicrobials. For Sh. sonnei almost 50% of isolates were resistant to ampicillin or trimethoprim and 15% were resistant to both of these antimicrobials. These results demonstrate that if antibiotic therapy had been indicated for infections with Sh. dysenteriae, Sh. flexneri, and Sh. boydii, then treatment with either ampicillin or trimethoprim may have been ineffective in almost 50% of cases and for Sh. sonnei, in 15% of cases. It is concluded that if it is necessary to commence treatment before the results of laboratory-based sensitivity tests are available, the best options would be to use nalidixic acid for children and a fluoroquinolone antibiotic such as ciprofloxacin or ofloxacin, for adults.

References

Sep 1, 1992·The Journal of Antimicrobial Chemotherapy·M L Bennish, M A Salam
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Citations

Mar 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M L ReplogleP R Cieslak
May 18, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Beletshachew ShiferawPaul Cieslak
Jul 3, 1999·The Pediatric Infectious Disease Journal·V PradoM M Levine
Mar 1, 2005·Journal of Pediatric Gastroenterology and Nutrition·Elif N OzmertDeniz Gür
Jun 9, 2004·Seminars in Pediatric Infectious Diseases·Larry K Pickering
Apr 13, 2005·Seminars in Pediatric Infectious Diseases·Miguel O'RyanLarry K Pickering
Oct 11, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Elif Nursel ÖzmertDeniz Gür
Nov 4, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T CheastyE J Threlfall
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Mar 30, 2000·Infectious Disease Clinics of North America·E L LópezM M Contrini

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