Increasing incidence of CD44v7/8 epitope expression during uterine cervical carcinogenesis

International Journal of Cancer. Journal International Du Cancer
P DallP Herrlich

Abstract

Splice variants of the cell surface glycoprotein CD44 (CD44v) have been implicated in the progression of various human tumors. In the present study, we have examined the expression pattern of a CD44v epitope encoded by the adjacent variant exons v7 and v8 during human cervical carcinogenesis. While only l/ll normal cervical squamous epithelia was positive for this epitope by immunohistochemistry, 4/21 samples of low-grade squamous intra-epithelial lesions (LSIL), 17/35 samples of high-grade squamous intra-epithelial lesions (HSIL), 11/12 samples of the HSIL subgroup of carcinomas in situ and 17/17 cases of invasive cervical carcinoma showed CD44v7/8 epitope expression. In addition to CD44 variant expression, we have analyzed 67 lesions for the presence of HPV16/18-DNA using PCR. Most of the samples expressing the v7/8 epitope were also HPV16-positive (29/32), whereas only 17/35 of the v7/8-negative samples were HPV16-positive. HPV18 DNA was found in only one invasive carcinoma. Our data suggests that high-risk HPV infection may precede CD44v7/8 expression and that the number of samples expressing the CD44v7/8 epitope increases during carcinogenesis and reaches nearly 100% at the carcinoma in situ stage. This CD44 epitope could,...Continue Reading

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Citations

Jan 20, 1999·Molecular Pathology : MP·R J Sneath, D C Mangham
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P. SpeiserN. F. Hacker
May 21, 2016·Stem Cells International·Ranjeeta Thapa, George D Wilson
Oct 19, 2001·Gynecologic Oncology·M WobusL S Sherman
Dec 6, 2001·Gynecologic Oncology·A AyhanA Ayhan
Jun 9, 2001·Applied Immunohistochemistry & Molecular Morphology : AIMM·G KayaN Gross
Jun 17, 1999·International Journal of Cancer. Journal International Du Cancer·L HeflerC Kainz
Apr 22, 1997·International Journal of Cancer. Journal International Du Cancer·P SpeiserC Kainz
Feb 5, 2005·Cancer Immunology, Immunotherapy : CII·Peter DallDieter Niederacher
Jul 12, 2005·Archives of Gynecology and Obstetrics·L-C HornR Martin
Sep 14, 2019·Journal of Oral and Maxillofacial Pathology : JOMFP·Mithilesh N MishraDeepak Bhargava
Apr 25, 2003·Critical Reviews in Oncology/hematology·Tracey A MartinWen G Jiang

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