Abstract
Splice variants of the cell surface glycoprotein CD44 (CD44v) have been implicated in the progression of various human tumors. In the present study, we have examined the expression pattern of a CD44v epitope encoded by the adjacent variant exons v7 and v8 during human cervical carcinogenesis. While only l/ll normal cervical squamous epithelia was positive for this epitope by immunohistochemistry, 4/21 samples of low-grade squamous intra-epithelial lesions (LSIL), 17/35 samples of high-grade squamous intra-epithelial lesions (HSIL), 11/12 samples of the HSIL subgroup of carcinomas in situ and 17/17 cases of invasive cervical carcinoma showed CD44v7/8 epitope expression. In addition to CD44 variant expression, we have analyzed 67 lesions for the presence of HPV16/18-DNA using PCR. Most of the samples expressing the v7/8 epitope were also HPV16-positive (29/32), whereas only 17/35 of the v7/8-negative samples were HPV16-positive. HPV18 DNA was found in only one invasive carcinoma. Our data suggests that high-risk HPV infection may precede CD44v7/8 expression and that the number of samples expressing the CD44v7/8 epitope increases during carcinogenesis and reaches nearly 100% at the carcinoma in situ stage. This CD44 epitope could,...Continue Reading
References
Oct 1, 1992·Gynecologic Oncology·J NoumoffJ Mikuta
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G R ScreatonJ I Bell
Nov 22, 1991·Science·H zur Hausen
Apr 5, 1991·Cell·U GünthertP Herrlich
Apr 6, 1990·Science·B A WernessP M Howley
Apr 1, 1990·Journal of Virological Methods·M M AnceschiE V Cosmi
Dec 21, 1990·Cell·M ScheffnerP M Howley
Jan 15, 1989·International Journal of Cancer. Journal International Du Cancer·P G FuchsH Pfister
Jan 7, 1989·BMJ : British Medical Journal·L S YoungC B Woodman
Nov 26, 1994·Lancet·J W MulderS T Pals
Feb 8, 1995·International Journal of Cancer. Journal International Du Cancer·P DallH Ponta
Mar 11, 1995·Lancet·M KaufmannP Herrlich
Oct 23, 1993·Lancet·B MayerJ P Johnson
Jan 1, 1995·Journal of Virology·T BauknechtH Zur Hausen
Jun 1, 1994·Carcinogenesis·I HerrP Angel
Aug 28, 1993·Lancet·S B FoxJ Fawcett
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·L ChenK E Hellström
Jan 1, 1993·Gynecologic Oncology·H IkenbergA Pfleiderer
Apr 1, 1993·The Journal of Experimental Medicine·G KoopmanS T Pals
Citations
Jan 20, 1999·Molecular Pathology : MP·R J Sneath, D C Mangham
Apr 17, 1998·Histopathology·E DaraiJ Y Scoazec
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P. SpeiserN. F. Hacker
Aug 1, 1997·Gynecologic Oncology·P DallH Ponta
May 21, 2016·Stem Cells International·Ranjeeta Thapa, George D Wilson
Jan 6, 2000·Gynecologic Oncology·G CallagyE Kay
Sep 30, 1999·Gynecologic Oncology·D LuK Iczkowski
Oct 19, 2001·Gynecologic Oncology·M WobusL S Sherman
Dec 6, 2001·Gynecologic Oncology·A AyhanA Ayhan
Jun 9, 2001·Applied Immunohistochemistry & Molecular Morphology : AIMM·G KayaN Gross
Jun 17, 1999·International Journal of Cancer. Journal International Du Cancer·L HeflerC Kainz
Apr 22, 1997·International Journal of Cancer. Journal International Du Cancer·P SpeiserC Kainz
Feb 5, 2005·Cancer Immunology, Immunotherapy : CII·Peter DallDieter Niederacher
Jul 12, 2005·Archives of Gynecology and Obstetrics·L-C HornR Martin
Sep 14, 2019·Journal of Oral and Maxillofacial Pathology : JOMFP·Mithilesh N MishraDeepak Bhargava
Jun 12, 1999·The Journal of Pathology·M SaegusaI Okayasu
Apr 25, 2003·Journal of Cancer Research and Clinical Oncology·D T ReinP Dall
Apr 25, 2003·Critical Reviews in Oncology/hematology·Tracey A MartinWen G Jiang