Increasing incidence of group B streptococcus neonatal infections in the Netherlands is associated with clonal expansion of CC17 and CC23.

Scientific Reports
Dorota JamrozyStephen D Bentley

Abstract

Group B streptococcus (GBS) is the leading cause of neonatal invasive disease worldwide. In the Netherlands incidence of the disease increased despite implementation of preventive guidelines. We describe a genomic analysis of 1345 GBS isolates from neonatal (age 0-89 days) invasive infections in the Netherlands reported between 1987 and 2016. Most isolates clustered into one of five major lineages: CC17 (39%), CC19 (25%), CC23 (18%), CC10 (9%) and CC1 (7%). There was a significant rise in the number of infections due to isolates from CC17 and CC23. Phylogenetic clustering analysis revealed that this was caused by expansion of specific sub-lineages, designated CC17-A1, CC17-A2 and CC23-A1. Dating of phylogenetic trees estimated that these clones diverged in the 1960s/1970s, representing historical rather than recently emerged clones. For CC17-A1 the expansion correlated with acquisition of a new phage, carrying gene encoding a putative cell-surface protein. Representatives of CC17-A1, CC17-A2 and CC23-A1 clones were identified in datasets from other countries demonstrating their global distribution.

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Citations

Sep 29, 2020·Frontiers in Microbiology·Chiara CrestaniRuth N Zadoks
Aug 26, 2021·Infection and Drug Resistance·Alberto BerardiRoberta Creti
Sep 24, 2021·Journal of Medical Microbiology·Birta BaeringsdottirThordur Thorkelsson

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Methods Mentioned

BETA
PCA
PCR

Software Mentioned

Velvet
RAxML
hierBAPS
Evolview
LogCombiner
SAMtools
SSPACE
BEAST
bcftools
FastTree

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