Increasing incidence of meningococcal disease in Spain associated with a new variant of serogroup C

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
S BerrónJ A Vázquez

Abstract

Serogroup B has been the main cause of meningococcal disease in Spain since at least 1979, but in recent years an increase in the prevalence of infection due to serogroup C meningococci has been detected. In 1996, for the first time, most cases of meningococcal disease were caused by serogroup C strains. The sero/subtype of all serogroup C meningococci received from 1993 to June 1996 was determined, and the results showed that C:2b:P1.2,5, the most common phenotype in 1995 and 1996 (63% and 65%, respectively), represented only 4.8% of strains in 1993. The C:2b: P1.2,5 epidemic strains appear to be responsible for the high prevalence of serogroup C in Spain. One hundred fifty-one randomly selected serogroup C strains were analyzed by multilocus enzyme electrophoresis, ribotyping, and pulsed-field gel electrophoresis. Pulsed-field gel electrophoresis provided the most accurate information: more than 80% of the C:2b:P1.2,5 and C:2b:P1.2 isolates exhibited one of two very closely related profiles, while most of the C:2b:NST and C:2b:P1.5 strains had a pattern located at a genetic distance of 0.24 from those two profiles. The results show that C:2b:P1.2,5 strains represent a subclone or a genetic variant of the previously identified...Continue Reading

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Citations

Sep 28, 2004·International Journal of Technology Assessment in Health Care·Denis GetsiosJaime J Caro
Dec 19, 2008·Journal of Clinical Microbiology·Jesús CastillaAurelio Barricarte
Dec 25, 2002·Emerging Infectious Diseases·Belén AlcaláJulio A Vázquez
Dec 29, 2004·The Lancet Infectious Diseases·Matthew D Snape, Andrew J Pollard
May 30, 2009·Vaccine·Lee H HarrisonMary E Ramsay
May 30, 2009·Vaccine·Helen CampbellElizabeth Miller
Feb 22, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L. ArreazaJ.A. Vázquez
Jul 11, 2009·Journal of Medical Microbiology·Mark MuscatPaul Cuschieri
Nov 1, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Simone S Wildes, Allan R Tunkel
Dec 23, 2006·Expert Review of Vaccines·Ray Borrow, Elizabeth Miller
Jan 22, 2015·Expert Review of Vaccines·Jane WhelanMirna Robert-Du Ry van Beest Holle
Apr 14, 2005·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·J A Soult Rubio, M Muñoz Sáez

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