Increasing intracellular magnesium levels with the 31-amino acid MgtS protein

Proceedings of the National Academy of Sciences of the United States of America
Hanbo WangGisela Storz

Abstract

Synthesis of the 31-amino acid, inner membrane protein MgtS (formerly denoted YneM) is induced by very low Mg2+ in a PhoPQ-dependent manner in Escherichia coli Here we report that MgtS acts to increase intracellular Mg2+ levels and maintain cell integrity upon Mg2+ depletion. Upon development of a functional tagged derivative of MgtS, we found that MgtS interacts with MgtA to increase the levels of this P-type ATPase Mg2+ transporter under Mg2+-limiting conditions. Correspondingly, the effects of MgtS upon Mg2+ limitation are lost in a ∆mgtA mutant, and MgtA overexpression can suppress the ∆mgtS phenotype. MgtS stabilization of MgtA provides an additional layer of regulation of this tightly controlled Mg2+ transporter and adds to the list of small proteins that regulate inner membrane transporters.

References

Jun 1, 1997·Molecular Microbiology·Y ShotlandA B Oppenheim
Jul 11, 2001·Genes & Development·K M WassarmanS Gottesman
Oct 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Oren KobilerAmos B Oppenheim
Jun 19, 2003·Journal of Bacteriology·Shu MinagawaRyutaro Utsumi
Jul 16, 2004·Journal of Proteome Research·Mahel ZeghoufJack F Greenblatt
Jan 20, 2006·Molecular Microbiology·Frank FührerFranz Narberhaus
Apr 18, 2006·Cell·Michael J CromieEduardo A Groisman
Jan 10, 2008·Cellular Microbiology·Lynne R Prost, Samuel I Miller
Jan 18, 2008·The EMBO Journal·Eric Alix, Anne-Béatrice Blanc-Potard
Jan 6, 2009·Molecular Microbiology·Matthew R HemmKenneth E Rudd
Dec 31, 2009·PLoS Genetics·Andrew M Lippa, Mark Goulian
Jul 23, 2011·The Journal of Biological Chemistry·Fanette FontaineGisela Storz
Dec 14, 2011·Biochemical and Biophysical Research Communications·Eunna ChoiDongwoo Shin
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Errett C HobbsGisela Storz
Mar 19, 2013·Journal of Bacteriology·Elena Cardenal-Muñoz, Francisco Ramos-Morales
Oct 2, 2013·Annual Review of Genetics·Eduardo A GroismanMauricio H Pontes
Nov 22, 2013·Molecular Microbiology·Sun-Yang Park, Eduardo A Groisman
Feb 18, 2014·Current Opinion in Microbiology·Zachary D Dalebroux, Samuel I Miller
Mar 13, 2014·Annual Review of Biochemistry·Gisela StorzKumaran S Ramamurthi
Apr 22, 2014·Nature·Dijun DuBen F Luisi
Jan 16, 2015·Current Opinion in Microbiology·Michael E Salazar, Michael T Laub
Nov 17, 2016·Proceedings of the National Academy of Sciences of the United States of America·Aaron R GallLaszlo N Csonka

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Citations

Nov 8, 2017·Journal of Bacteriology·Tracy L Raivio
Feb 9, 2018·Nature Communications·Katharina E J JungnickelSimon Newstead
Feb 28, 2019·Molecular Omics·Alexandra KhitunSarah A Slavoff
Sep 11, 2019·Nucleic Acids Research·Mona Wu OrrShu-Bing Qian
Jun 6, 2019·MBio·Michael KnoppDan I Andersson
Jun 3, 2020·Journal of Bacteriology·Srujana S YadavalliJing Yuan
Apr 20, 2019·Frontiers in Cellular and Infection Microbiology·Malika MoussouniAnne-Béatrice Blanc-Potard
Aug 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jinki YeomEduardo A Groisman
Sep 3, 2019·Biochimica Et Biophysica Acta. General Subjects·Dursun Nizam KorkutFabien Darfeuille
Jun 20, 2018·Microbiology Spectrum·Anaïs Brosse, Maude Guillier
May 10, 2020·EcoSal Plus·Matthew R HemmGisela Storz
Aug 31, 2021·Journal of Bacteriology·Jordan J AoyamaGisela Storz
Oct 9, 2021·Annual Review of Microbiology·Eduardo A Groisman, Carissa Chan
Mar 30, 2021·The FEBS Journal·Ruth Steinberg, Hans-Georg Koch

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