Increasing macrolide resistance among Streptococcus agalactiae causing invasive disease in non-pregnant adults was driven by a single capsular-transformed lineage, Portugal, 2009 to 2015

Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
Elísia LopesThe Portuguese Group For The Study Of Streptococcal Infections

Abstract

We characterised Lancefield group B streptococcal (GBS) isolates causing invasive disease among non-pregnant adults in Portugal between 2009 and 2015. All isolates (n = 555) were serotyped, assigned to clonal complexes (CCs) by multilocus sequence typing and characterised by surface protein and pilus island gene profiling. Antimicrobial susceptibility was tested by disk diffusion and resistance genotypes identified by PCR. Overall, serotype Ia was most frequent in the population (31%), followed by serotypes Ib (24%) and V (18%). Serotype Ib increased significantly throughout the study period (p < 0.001) to become the most frequent serotype after 2013. More than 40% of isolates clustered in the CC1/alp3/PI-1+PI-2a genetic lineage, including most isolates of serotypes Ib (n = 110) and V (n = 65). Erythromycin and clindamycin resistance rates were 35% and 34%, respectively, both increasing from 2009 to 2015 (p < 0.010) and associated with CC1 and serotype Ib (p < 0.001). The Ib/CC1 lineage probably resulted from acquisition of the type Ib capsular operon in a single recombination event by a representative of the V/CC1 macrolide-resistant lineage. Expansion of the new serotype Ib/CC1 lineage resulted in increased macrolide resistan...Continue Reading

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Citations

Oct 10, 2018·The Pediatric Infectious Disease Journal·Erla S BjörnsdóttirKarl G Kristinsson
May 5, 2020·Critical Reviews in Microbiology·Katherine HayesLesley Cotter
Jul 28, 2019·Antimicrobial Resistance and Infection Control·Kaixin ZhouJingyong Sun
May 5, 2021·BMC Infectious Diseases·Rossella BaldanParham Sendi
Nov 18, 2021·The Journal of Infectious Diseases·Allison N DammannAdam J Ratner
Oct 3, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Xavier VuilleminAsmaa Tazi

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