Increasing metabolic co-morbidities are associated with higher risk of advanced fibrosis in nonalcoholic steatohepatitis

PloS One
Robert J WongRobert Gish

Abstract

Hepatic fibrosis and advanced fibrosis in particular is the strongest predictor of liver-related outcomes and mortality among nonalcoholic steatohepatitis (NASH) patients. Understanding prevalence and predictors of NASH with advanced fibrosis is critical for healthcare resource planning. Using a large U.S. clinical laboratory database from 10/1/2017-9/30/2018, adults negative for hepatitis B and hepatitis C and after excluding for alcoholic liver disease and pregnancy were evaluated for prevalence of F3 and F4 fibrosis using a systematic algorithm of five fibrosis-4 (FIB-4) criteria: Criteria 1 (≥F3: >2.67), Criteria 2 (2.67<F3≤4.12 and F4>4.12), Criteria 3 (2.67<F3≤3.15, F4>3.15), Criteria 4 (3.25<F3≤3.5, F4>3.5), Criteria 5 (3.25<F3≤4.12, F4>4.12). Metabolic co-morbidities evaluated included decreased high density lipoprotein (<40 mg/dL men, <50 mg/dL women), high triglycerides (≥150 mg/dL), elevated hemoglobin A1C (≥6.5%). Parallel analyses of patients with specific NAFLD/NASH ICD-9/10 codes from 10/1/2013-9/30/2018 were performed. Multivariate logistic regression models evaluated for predictors of ≥F3 fibrosis. Among patients with NAFLD/NASH ICD-9/10 codes, ≥F3 prevalence ranged from 4.35% - 6.90%, and F4 prevalence ranged ...Continue Reading

References

Aug 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna Ludovica FracanzaniSilvia Fargion
Apr 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Scott D HolmbergUNKNOWN Chronic Hepatitis Cohort Study (CHeCS) Investigators
Nov 28, 2013·Journal of Gastroenterology·Takashi NakaharaUNKNOWN Japan Study Group of Nonalcoholic Fatty Liver Disease
Jan 1, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert J WongAijaz Ahmed
Aug 16, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtRolf Hultcrantz
May 20, 2015·JAMA : the Journal of the American Medical Association·Maria AguilarRobert J Wong
Jun 10, 2015·JAMA : the Journal of the American Medical Association·Mary E Rinella
Dec 29, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiMark Wymer
Oct 12, 2016·The American Journal of Gastroenterology·Stuart McPhersonQuentin M Anstee
Feb 25, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Salvatore PettaAntonio Craxì
Jul 18, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naga ChalasaniArun J Sanyal
Jan 3, 2019·Journal of Gastroenterology and Hepatology·Hideki FujiiUNKNOWN Japan Study Group of Nonalcoholic Fatty Liver Disease

❮ Previous
Next ❯

Citations

Oct 1, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Sakura YamamuraTakuji Torimura
Feb 9, 2021·Clinical Liver Disease·Yumi Ando, Janice H Jou
Mar 9, 2021·Journal of Clinical and Experimental Hepatology·Nicolette VeracruzRobert J Wong

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SAS Studio
Quest Diagnostics Informatics Data Warehouse
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.