Increasing PET Use in Small Cell Lung Cancer: Survival Improvement and Stage Migration in the VA Central Cancer Registry

Journal of the National Comprehensive Cancer Network : JNCCN
Julian C HongJoseph K Salama

Abstract

Background: Accurate staging for small cell lung cancer (SCLC) is critical for determining appropriate therapy. The clinical impact of increasing PET adoption and stage migration is well described in non-small cell lung cancer but not in SCLC. The objective of this study was to evaluate temporal trends in PET staging and survival in the Veterans Affairs Central Cancer Registry and the impact of PET on outcomes. Patients and Methods: Patients diagnosed with SCLC from 2001 to 2010 were identified. PET staging, overall survival (OS), and lung cancer-specific survival (LCSS) were assessed over time. The impact of PET staging on OS and LCSS was assessed for limited-stage (LS) and extensive-stage (ES) SCLC. Results: From 2001 to 2010, PET use in a total of 10,135 patients with SCLC increased from 1.1% to 39.2%. Median OS improved for all patients (from 6.2 to 7.9 months), those with LS-SCLC (from 10.9 to 13.2 months), and those with ES-SCLC (from 5.0 to 7.0 months). Among staged patients, the proportion of ES-SCLC increased from 63.9% to 65.7%. Among 1,536 patients with LS-SCLC treated with concurrent chemoradiotherapy, 397 were staged by PET. In these patients, PET was associated with longer OS (median, 19.8 vs 14.3 months; hazard r...Continue Reading

References

Dec 3, 1992·The New England Journal of Medicine·J P PignonB Lebeau
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B JeremicG Radosavljevic-Asic
Jul 20, 2004·European Journal of Nuclear Medicine and Molecular Imaging·I BrinkE U Nitzsche
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey D BradleyBarry A Siegel
Dec 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel B FriedMark A Socinski
Sep 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ramaswamy GovindanJay Piccirillo
Oct 25, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B M FischerH H Hansen
Aug 19, 2007·The New England Journal of Medicine·Ben SlotmanUNKNOWN EORTC Radiation Oncology Group and Lung Cancer Group
Feb 20, 2008·Clinical Lung Cancer·Mridula VinjamuriJohn S Rogers
Feb 28, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Daniel MorgenszternRamaswamy Govindan
Nov 11, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Bruce E HillnerR Edward Coleman
Aug 22, 2009·Journal of the National Comprehensive Cancer Network : JNCCN·Donald A PodoloffRichard J Wong
Jul 3, 2009·The New England Journal of Medicine·Barbara FischerLiselotte Højgaard
Jul 8, 2009·Annals of Internal Medicine·Donna E MaziakMark N Levine
Mar 7, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mary Beth LandrumBarbara J McNeil
Jul 4, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michaela A DinanMorris Weinberger
Apr 24, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Eric P XanthopoulosRamesh Rengan
May 30, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Joseph K SalamaUNKNOWN Cancer and Leukemia Group B
Sep 19, 2014·World Journal of Gastrointestinal Oncology·María Del Carmen Gómez-MateoAntonio Ferrández-Izquierdo
Sep 19, 2014·World Journal of Gastrointestinal Oncology·Ambedkar Raj Kulandai VeluIlavarasi Sinduja
Jun 20, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ben J SlotmanSuresh Senan
Jun 27, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Elizabeth M GoreJeffrey D Bradley
Sep 28, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Matthew J BoyerJoseph K Salama
Dec 12, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yi-Long WuUNKNOWN ENSURE FASTACT-2 and ASPIRATION Investigators

❮ Previous
Next ❯

Citations

Aug 8, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Julian C Hong, Joseph K Salama
Aug 8, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·Prakash ManoharanCorinne Faivre-Finn
Nov 7, 2019·Seminars in Oncology·Mark KleinApar Kishor Ganti
Jan 14, 2022·European Journal of Nuclear Medicine and Molecular Imaging·Sofia C VazLioe-Fee de Geus-Oei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Jenny J LinJuan P Wisnivesky
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
M ZhouJ Sun
Seminars in Respiratory and Critical Care Medicine
Gregory P Kalemkerian
© 2022 Meta ULC. All rights reserved