Increasing plasma thyroxine levels during late embryogenesis and hatching in the chicken are not caused by an increased sensitivity of the thyrotropes to hypothalamic stimulation

The Journal of Endocrinology
Bert De GroefV M Darras

Abstract

The hatching process in the chicken is accompanied by dramatic changes in plasma thyroid hormones. The cause of these changes, though crucial for hatching and the onset of endothermy, is not known. One hypothesis is that the pituitary gland becomes more sensitive to hypothalamic stimulation during this period. We have tested whether the responsiveness of the thyrotropes to hypothalamic stimuli changes throughout the last week of embryonic development and hatching by studying the mRNA expression of receptors involved in the control of the secretory activity of this cell type. We used a real-time PCR set-up to quantify whole pituitary mRNA expression of the beta subunit of thyrotrophin (TSH-beta), type 1 thyrotrophin-releasing hormone receptor (TRH-R1), corticotrophin-releasing hormone receptors (CRH-R1 and CRH-R2) and somatostatin subtype receptor 2 (SSTR2) on every day of the last week of embryonic development, including the day of hatch and the first day of posthatch life. The thyrotrope-specific expression was investigated by a combination of in situ hybridization with immunohistochemistry at selected ages. Although TSH-beta mRNA levels increased towards day 19 of incubation (E19), the expression of CRH-R2 and TRH-R1 mRNA by ...Continue Reading

Citations

Feb 14, 2016·General and Comparative Endocrinology·Yugo WatanabeBert De Groef
Dec 21, 2010·General and Comparative Endocrinology·Laura E EllestadTom E Porter
Oct 12, 2010·Domestic Animal Endocrinology·S V H GrommenB De Groef
Aug 18, 2009·Domestic Animal Endocrinology·S V GrommenB De Groef
Apr 11, 2008·General and Comparative Endocrinology·Sylvia V H GrommenBert De Groef

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