Increasing Prescription of Opiates and Mortality in Patients With Inflammatory Bowel Diseases in England

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Nicholas E BurrVenkataraman Subramanian

Abstract

The prescription of opiate medications is increasing. Individuals with inflammatory bowel diseases (IBD) can develop serious complications from opiate use, but few data are available on the prescription of these drugs to patients with IBD. We examined trends in prescriptions of opiates and their association with all-cause mortality in individuals with IBD. We performed a retrospective cohort study of 3517 individuals with Crohn's disease (CD) and 5349 with ulcerative colitis (UC) using the primary care database ResearchOne, which holds de-identified clinical and administrative information from the health records of approximately 6 million persons (more than 10% of the total population) in England. We explored trends in prescriptions of all opiates, codeine, tramadol, or strong opiates, separately from 1990 through September 14, 2014. Associations between opiates and all-cause mortality were examined using propensity score-matched analysis. There was a statistically significant increase in the prescription of opiate medications, with 10% of subjects receiving an opiate prescription from 1990 through 1993 compared to 30% from 2010 through 2013 (chi-square for trend, P < .005). Prescription of strong opiates was significantly asso...Continue Reading

Citations

Mar 13, 2019·JAMA : the Journal of the American Medical Association·Chao ZengYuqing Zhang
Jan 4, 2020·Clinical and Translational Gastroenterology·Melanie KienzlRudolf Schicho
Dec 19, 2019·European Journal of Gastroenterology & Hepatology·Louise SweeneyChristine Norton
Jul 3, 2020·Journal of Crohn's & Colitis·Keith Sultan, Arun Swaminath
Feb 27, 2020·Inflammatory Bowel Diseases·Lisa MalterAdam S Cheifetz
Aug 22, 2020·Therapeutic Advances in Gastroenterology·Offir UkashiUri Kopylov
May 10, 2018·Journal of Crohn's & Colitis·Shirley Cohen-MekelburgCarl Crawford
May 8, 2020·Der Schmerz·Winfried HäuserUNKNOWN Koautoren für die Konsensusgruppe der 2. Aktualisierung der S3-Leitlinie LONTS
Jul 19, 2020·International Journal of Colorectal Disease·Mishal RejaVinod Rustgi
Aug 25, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Blake NiccumHamed Khalili
Nov 6, 2020·Pharmacy : Journal of Pharmacy, Education and Practice·Sharmila S PrasadMarjorie M Walker
Jul 20, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tarun ChhibbaChristopher Ma
Feb 15, 2021·Journal of Crohn's & Colitis·Mirabella ZhaoJohan Burisch
Dec 18, 2021·Scandinavian Journal of Gastroenterology·Joshua Wynne, Patricia Kozuch

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