Increasing prevalence of antimicrobial resistance in Streptococcus pneumoniae in Kuwait: implications for therapy

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
E M MokaddasM John Albert

Abstract

From 2001 to 2004, 824 consecutive Streptococcus pneumoniae isolates obtained from all the teaching hospitals and primary-care centers serving all of Kuwait were studied for their susceptibility to a number of antibiotics. Of these, 514 (63%) were resistant to penicillin, 55% of which were of intermediate resistance, with a minimum inhibitory concentration (MIC) of 0.16-1 microg/ml, and 8% were of full resistance (MIC > or =2 microg/ml). The prevalence of penicillin resistance was significantly higher among the eye isolates than the rest of the isolates combined. Resistance across all classes of antibiotics was more common with the isolates from blood and cerebrospinal fluid (CSF). Decreased susceptibility to ceftriaxone, cefotaxime, imipenem, meropenem, erythromycin, and cotrimoxazole was observed in 15%, 12.8%, 10.2%, 8.6%, 42%, and 69% of isolates, respectively. Multidrug-resistant S. pneumoniae was isolated mostly from invasive diseases. There has been a remarkable increase in the prevalence of drug-resistant S. pneumoniae isolates in Kuwait over the past 20 years, and Kuwait has thus joined the league of hyperendemic countries for penicillin-resistant S. pneumoniae (PRSP). It is also conceivable that Kuwait, with a large e...Continue Reading

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Citations

Jul 10, 2013·Asian Pacific Journal of Tropical Biomedicine·Belay AnagawChandrashekhar Unakal
Aug 14, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Kiyoko TomochikaSusumu Furukawa
Jun 27, 2017·Journal of Medical Microbiology·Grace El MoujaberMonzer Hamze

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