Increasing prevalence of ESBL production among Irish clinical Enterobacteriaceae from 2004 to 2008: an observational study.

BMC Infectious Diseases
Jérôme FennellMartin Cormican

Abstract

Extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae infections are associated with delayed initiation of appropriate treatment, poor outcomes and increased hospital stay and expense. Although initially associated with healthcare settings, more recent international reports have shown increasing isolation of ESBLs in the community. Both hospital and community ESBL epidemiology in Ireland are poorly defined. This report describes clinical and laboratory data from three hospitals over 4.5 years. All significant isolates of Enterobacteriaceae were subjected to standardized antimicrobial susceptibility testing and screening for ESBL production. Available patient data from hospital databases were reviewed. The database included 974 ESBL producing organisms from 464 patients. Urine and blood isolates represented 84% and 3% of isolates respectively. E. coli predominated (90.9%) followed by K. pneumoniae (5.6%). The majority of patients (n = 246, 53.0%) had been admitted to at least one of the study hospitals in the year prior to first isolation of ESBL. The overall 30-day all-cause mortality from the date of culture positivity was 9.7% and the 1 year mortality was 61.4%. A Cox regression analysis showed age over 60, male g...Continue Reading

References

Feb 18, 1999·JAMA : the Journal of the American Medical Association·J WienerR A Weinstein
Apr 3, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E LautenbachN O Fishman
Oct 25, 2003·Antimicrobial Agents and Chemotherapy·Corinne ArpinClaudine Quentin
Jun 19, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L PatersonVictor L Yu
Sep 7, 2004·The Journal of Antimicrobial Chemotherapy·N WoodfordD M Livermore
Mar 8, 2005·Journal of Public Health·UNKNOWN Health Protection Agency, Communicable Disease Surveillance Centre
Jul 12, 2005·The Journal of Antimicrobial Chemotherapy·D M Livermore, P M Hawkey
Dec 20, 2005·The Journal of Headache and Pain·Irene FavierMichel D Ferrari
Feb 1, 2006·Irish Journal of Medical Science·M Ni ChulainM Cormican
Nov 3, 2006·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Su Young LeeDavid P Nicolau
Oct 10, 2008·The Journal of Antimicrobial Chemotherapy·David M LivermoreUNKNOWN BSAC Working Parties on Resistance Surveillance
Jul 23, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ronen Ben-AmiYehuda Carmeli
Oct 20, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Erin O'FallonErika M C D'Agata

❮ Previous
Next ❯

Citations

Feb 5, 2013·Current Infectious Disease Reports·Betsy Foxman, Miatta Buxton
Apr 16, 2013·Journal of the American Medical Directors Association·Felice MarinosciRaffaele Antonelli Incalzi
Mar 15, 2015·International Journal of Medical Microbiology : IJMM·Claudia SteinMathias W Pletz
Jul 6, 2014·The Journal of Antibiotics·Yanchun WangPing He
Oct 21, 2016·Irish Journal of Medical Science·C O'ConnorC P Dunne
Jul 6, 2021·Saudi Journal of Biological Sciences·Kawther AabedSaleha Alzahrani
Aug 10, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Ian CockSandy Van Vuuren

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.