Abstract
There is worldwide concern with the increasing rates of infections due to multiresistant Candida isolates reported in tertiary medical centers. We checked for historical trends in terms of prevalence rates and antifungal susceptibility of the Candida haemulonii species complex in our yeast stock culture collected during the last 11 years. The isolates were identified by sequencing the rDNA internal transcribed spacer (ITS) region, and antifungal susceptibility tests for amphotericin B, voriconazole, fluconazole, anidulafungin, and 5-fluorocytosine were performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. A total of 49 isolates were identified as Candida haemuloniisensu stricto (n = 21), followed by C. haemulonii var. vulnera (n = 15) and C. duobushaemulonii (n = 13), including 38 isolates cultured from patients with deep-seated Candida infections. The prevalence of the C. haemulonii species complex increased from 0.9% (18 isolates among 1931) in the first period (December 2008 to June 2013) to 1.7% (31 isolates among 1868) in the second period (July 2014 to December 2019) of analysis (p = 0.047). All isolates tested exhibited high minimum inhibition concentrations for amphotericin B and flucona...Continue Reading
References
Jul 1, 1987·Molecular Biology and Evolution·N Saitou, M Nei
May 31, 2002·Journal of Clinical Microbiology·Laura RoderoJuan L Rodríguez-Tudela
Apr 13, 2007·Journal of Clinical Microbiology·Zia U KhanRachel Chandy
Feb 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mi-Na KimDong Wook Ryang
Oct 27, 2009·Molecular Biology and Evolution·Manolo GouyOlivier Gascuel
Sep 18, 2010·Diagnostic Microbiology and Infectious Disease·Michael A PfallerRonald N Jones
Feb 3, 2011·Journal of Korean Medical Science·Sunyong KimJun Seong Son
Mar 8, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J CrouzetN Bourgeois
Aug 17, 2012·Journal of Clinical Microbiology·Marisol Dominguez MuroLíbera Maria Dalla-Costa
Sep 7, 2012·Journal of Clinical Microbiology·E Cendejas-BuenoT Boekhout
Mar 25, 2015·Medical Mycology·Laszlo IrinyiWieland Meyer
Apr 19, 2015·BMC Infectious Diseases·Karina Bellinghausen MerseguelArnaldo Lopes Colombo
Feb 20, 2016·Emerging Infectious Diseases·João Nobrega de AlmeidaGil Benard
May 26, 2016·Emerging Microbes & Infections·Anil KumarAnuradha Chowdhary
Aug 19, 2016·Journal of Clinical Microbiology·Xin HouYing-Chun Xu
Jan 19, 2017·Emerging Infectious Diseases·Ronen Ben-AmiTalya Finn
Nov 3, 2017·Current Opinion in Infectious Diseases·Arnaldo L ColomboJesus Guinea
Dec 19, 2018·Nature Communications·José F MuñozChristina A Cuomo
Mar 22, 2019·Open Forum Infectious Diseases·Michael A PfallerRonald N Jones
Jul 10, 2019·Journal of Fungi·Brendan R JacksonTom Chiller
Jun 27, 2020·Frontiers in Genetics·Lalitha GadeAnastasia P Litvintseva
Citations
Oct 7, 2020·Journal of Fungi·Lívia S RamosAndré L S Santos
Dec 3, 2020·Journal of Fungi·Hans CarolusPatrick Van Dijck
Jun 17, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D K B RodriguesM S C Melhem