Increasing Prevalence of Multidrug-Resistant Candida haemulonii Species Complex among All Yeast Cultures Collected by a Reference Laboratory over the Past 11 Years

Journal of Fungi
Soraia Lopes LimaArnaldo Lopes Colombo

Abstract

There is worldwide concern with the increasing rates of infections due to multiresistant Candida isolates reported in tertiary medical centers. We checked for historical trends in terms of prevalence rates and antifungal susceptibility of the Candida haemulonii species complex in our yeast stock culture collected during the last 11 years. The isolates were identified by sequencing the rDNA internal transcribed spacer (ITS) region, and antifungal susceptibility tests for amphotericin B, voriconazole, fluconazole, anidulafungin, and 5-fluorocytosine were performed by the Clinical and Laboratory Standards Institute (CLSI) microbroth method. A total of 49 isolates were identified as Candida haemuloniisensu stricto (n = 21), followed by C. haemulonii var. vulnera (n = 15) and C. duobushaemulonii (n = 13), including 38 isolates cultured from patients with deep-seated Candida infections. The prevalence of the C. haemulonii species complex increased from 0.9% (18 isolates among 1931) in the first period (December 2008 to June 2013) to 1.7% (31 isolates among 1868) in the second period (July 2014 to December 2019) of analysis (p = 0.047). All isolates tested exhibited high minimum inhibition concentrations for amphotericin B and flucona...Continue Reading

References

Jul 1, 1987·Molecular Biology and Evolution·N Saitou, M Nei
May 31, 2002·Journal of Clinical Microbiology·Laura RoderoJuan L Rodríguez-Tudela
Feb 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mi-Na KimDong Wook Ryang
Feb 3, 2011·Journal of Korean Medical Science·Sunyong KimJun Seong Son
Mar 8, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J CrouzetN Bourgeois
Aug 17, 2012·Journal of Clinical Microbiology·Marisol Dominguez MuroLíbera Maria Dalla-Costa
Apr 19, 2015·BMC Infectious Diseases·Karina Bellinghausen MerseguelArnaldo Lopes Colombo
Feb 20, 2016·Emerging Infectious Diseases·João Nobrega de AlmeidaGil Benard
Jan 19, 2017·Emerging Infectious Diseases·Ronen Ben-AmiTalya Finn
Nov 3, 2017·Current Opinion in Infectious Diseases·Arnaldo L ColomboJesus Guinea
Mar 22, 2019·Open Forum Infectious Diseases·Michael A PfallerRonald N Jones
Jul 10, 2019·Journal of Fungi·Brendan R JacksonTom Chiller

❮ Previous
Next ❯

Citations

Jun 17, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D K B RodriguesM S C Melhem

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Software Mentioned

Sequencher
SeView

Related Concepts

Related Feeds

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.