Abstract
From January 1981 to December 2003, susceptibility to nalidixic acid was tested in 10,504 nontyphoid Salmonella enterica isolates from patients with acute enteric disease in Gipuzkoa, Spain. The prevalence of nalidixic acid resistance steadily increased from less than 0.5% before 1991 to 38.5% in 2003, mainly due to the increase in resistance among isolates of the most prevalent serovar, S. enterica serovar Enteritidis. For nalidixic acid-resistant isolates, the ciprofloxacin MIC was eightfold higher than that for susceptible isolates, and the nalidixic acid-resistant isolates contained a single point mutation in the gyrA gene (at codons for Ser83 or Asp87). The same mutations were found in a sample of nalidixic acid-resistant nontyphoid Salmonella strains isolated between 1999 and 2003 from retail food for human consumption. In 2003, we identified five S. enterica serovar Typhimurium clinical isolates with high-level fluoroquinolone resistance (ciprofloxacin MIC, 16 microg/ml) with two point mutations in the gyrA gene (coding for Ser83-->Phe and Asp87-->Asn) and one point mutation in the parC gene (coding for Ser80-->Arg). Strict sanitary controls are needed to avoid the spread of ciprofloxacin-resistant serovar Typhimurium is...Continue Reading
References
Jan 1, 1992·The Journal of Antimicrobial Chemotherapy·T M Reid
Jun 16, 1990·Lancet·L J PiddockR Wise
Oct 1, 1995·FEMS Microbiology Letters·K GensbergL J Piddock
Nov 27, 1993·Lancet·E Perez-TralleroI Ayestaran
Jul 1, 1997·Emerging Infectious Diseases·H HerikstadF J Angulo
Mar 21, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F J VasalloE Bouza
Jun 25, 1999·The Journal of Antimicrobial Chemotherapy·A HakanenP Huovinen
Sep 3, 1999·Antimicrobial Agents and Chemotherapy·E GiraudE Chaslus-Dancla
Apr 19, 2000·Antimicrobial Agents and Chemotherapy·G PratsF Navarro
Apr 19, 2000·Antimicrobial Agents and Chemotherapy·E GiraudE Chaslus-Dancla
Jul 13, 2000·Veterinary Microbiology·I LaconchaJ Garaizar
Dec 5, 2000·The Journal of Antimicrobial Chemotherapy·J BreuilE Collatz
Feb 13, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J OteoJ L Gómez-Garcés
Feb 27, 2001·The Journal of Antimicrobial Chemotherapy·S CruchagaM A Usera
Feb 22, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E. John ThrelfallBernard Rowe
May 9, 2002·Emerging Infectious Diseases·Kåre MølbakHenrik C Wegener
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Frank Møller AarestrupE John Threlfall
Feb 27, 2003·Emerging Infectious Diseases·Hideo NakayaHaruo Watanabe
Mar 13, 2003·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·E J ThrelfallG Edwards
Mar 13, 2003·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·J M MarimónC López-Lopategui
Apr 23, 2003·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Heike Hansen, Peter Heisig
May 23, 2003·Antimicrobial Agents and Chemotherapy·Beatriz GuerraReiner Helmuth
Citations
Feb 25, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S MarakiY Tselentis
Sep 22, 2007·Foodborne Pathogens and Disease·Sameer Al-ZenkiFrank M Aarestrup
Mar 11, 2011·Journal of Clinical Microbiology·Michael P RyanCatherine C Adley
Dec 21, 2006·Emerging Infectious Diseases·François-Xavier WeillPatrick A D Grimont
Jan 5, 2011·Emerging Infectious Diseases·Manar Al-MashhadaniChristopher M Parry
Jul 22, 2009·Biomedical and Environmental Sciences : BES·Min ZhuZi-Jun Wang
Mar 10, 2005·Basic & Clinical Pharmacology & Toxicology·Frank M Aarestrup
Jan 19, 2007·Alimentary Pharmacology & Therapeutics·M E FalagasI A Bliziotis
Mar 4, 2014·Diagnostic Microbiology and Infectious Disease·Maria Jorge CamposAlberto Quesada
Jun 8, 2013·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Abeer Ahmed RushdyNeveen Mohamed Saleh
Oct 5, 2010·FEMS Microbiology Letters·Maria KarczmarczykSéamus Fanning
Apr 12, 2011·Journal of Food Protection·K E LeeY H Lee
Dec 19, 2006·Journal of Medical Microbiology·Hayath KownharUsha Anand Rao
May 26, 2005·The Journal of Antimicrobial Chemotherapy·A MurrayD J Brown
Sep 29, 2007·Journal of Food Protection·Leonardo A Boscán-DuqueArmando E Hoet
Jun 21, 2019·PLoS Neglected Tropical Diseases·Cassandra AldrichDaniel Eibach
Mar 18, 2006·Journal of Food Protection·S ZhaoD G White
Jul 4, 2021·The Veterinary Journal·D E GomezJ S Weese