Increasing synovitis and bone marrow lesions are associated with incident joint tenderness in hand osteoarthritis

Annals of the Rheumatic Diseases
Ida K HaugenTore K Kvien

Abstract

To explore whether changes of MRI-defined synovitis and bone marrow lesions (BMLs) are related to changes in joint tenderness in a 5-year longitudinal study of the Oslo hand osteoarthritis (OA) cohort. We included 70 patients (63 women, mean (SD) age 67.9 (5.5) years). BMLs and contrast-enhanced synovitis in the distal and proximal interphalangeal joints were evaluated on 0-3 scales in n=69 and n=48 patients, respectively. Among joints without tenderness at baseline, we explored whether increasing/incident synovitis and BMLs were associated with incident joint tenderness using generalised estimating equations. Among joints with tenderness at baseline, we explored whether decreasing or resolution of synovitis and BMLs were associated with loss of joint tenderness. We adjusted for age, sex, body mass index, follow-up time and changes in radiographic OA. Among joints without tenderness at baseline, increasing/incident synovitis and BMLs were seen in 45 of 220 (20.5%) and 47 of 312 (15.1%) joints, respectively. Statistically significant associations to incident joint tenderness were found for increasing/incident synovitis (OR=2.66, 95% CI 1.38 to 5.11) and BMLs (OR=2.85, 95% CI 1.23 to 6.58) independent of structural progression. W...Continue Reading

References

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Dec 3, 2013·The Journal of Rheumatology·Ida K HaugenPhilip G Conaghan

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Citations

Dec 29, 2015·Osteoarthritis and Cartilage·Y WangF M Cicuttini
Dec 25, 2015·Annals of the Rheumatic Diseases·Ida K Haugen, Hilde B Hammer
Oct 1, 2016·Scandinavian Journal of Rheumatology·I K Haugen
Feb 2, 2017·Scandinavian Journal of Rheumatology·K MagnussonI K Haugen
Jul 7, 2017·SLAS Discovery·David A Walsh, Joanne Stocks
May 20, 2020·Radiology·Frank W RoemerAli Guermazi
Oct 19, 2016·Current Opinion in Rheumatology·Carla R Scanzello
Dec 23, 2017·The British Journal of Radiology·Daichi HayashiAli Guermazi
Oct 12, 2018·Nature Reviews. Rheumatology·Michelle MarshallKrysia Dziedzic
Feb 6, 2017·Arthritis Research & Therapy·Alexander Mathiessen, Philip G Conaghan
Jun 20, 2020·Arthritis Care & Research·Sjoerd van BeestFéline P B Kroon

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