Increasing the endogenous NO level causes catalase inactivation and reactivation of intercellular apoptosis signaling specifically in tumor cells

Redox Biology
Georg Bauer

Abstract

Tumor cells generate extracellular superoxide anions and are protected against intercellular apoptosis-inducing HOCl- and NO/peroxynitrite signaling through the expression of membrane-associated catalase. This enzyme decomposes H2O2 and thus prevents HOCl synthesis. It efficiently interferes with NO/peroxynitrite signaling through oxidation of NO and decomposition of peroxynitrite. The regulatory potential of catalase at the crosspoint of ROS and RNS chemical biology, as well as its high local concentration on the outside of the cell membrane of tumor cells, establish tight control of intercellular signaling and thus prevent tumor cell apoptosis. Therefore, inhibition of catalase or its inactivation by singlet oxygen reactivate intercellular apoptosis-inducing signaling. Nitric oxide and peroxynitrite are connected with catalase in multiple and meaningful ways, as (i) NO can be oxidated by compound I of catalase, (ii) NO can reversibly inhibit catalase, (iii) peroxynitrite can be decomposed by catalase and (iv) the interaction between peroxynitrite and H2O2 leads to the generation of singlet oxygen that inactivates catalase. Therefore, modulation of the concentration of free NO through addition of arginine, inhibition of argina...Continue Reading

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Citations

Apr 7, 2017·Biological Chemistry·Christophe Glorieux, Pedro Buc Calderon
Oct 27, 2017·International Journal of Molecular Sciences·Yasuyoshi MiyataHideki Sakai
Mar 26, 2019·Advanced Materials·Lian-Hua FuPeng Huang
Feb 20, 2020·Journal of Biomolecular Structure & Dynamics·Surendra KumarDharmendra K Yadav
Nov 7, 2019·Oxidative Medicine and Cellular Longevity·Angela Privat-MaldonadoSander Bekeschus
Jul 21, 2020·Journal of Experimental Botany·John T Hancock, David Veal
Jul 19, 2019·Oxidative Medicine and Cellular Longevity·Maksudbek YusupovAnnemie Bogaerts
Feb 21, 2018·Physical Chemistry Chemical Physics : PCCP·C C W VerlacktA Bogaerts
Mar 13, 2021·Free Radical Biology & Medicine·Sander BekeschusAnke Schmidt
Nov 21, 2017·Journal of Inorganic Biochemistry·Georg Bauer

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Methods Mentioned

BETA
dissection
phase contrast microscopy

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