Increasing the extensional viscosity of silicone oil reduces the tendency for emulsification

Retina
Rachel L WilliamsD Wong

Abstract

The purpose was to study the emulsification of silicone oil tamponade agents that cause clinical complications. This study aimed to increase the emulsification resistance of silicone oil 1,000 to be at least as resistant as silicone oil 5,000 while maintaining the shear viscosity <5,000 mPa/s to aid injection and removal. High-molecular-weight (423 kDa) poly(dimethyl siloxane) was added to silicone oil 1,000 at 5% and 10% w/w concentration. The shear and extensional viscosity of 1,000 and 5,000, a 50:50 mixture of 1,000 and 5,000 and 5% and 10% w/w additive blends, respectively, of silicone oil were measured using capillary breakup extensional, rotational shear, and capillary extrusion rheometry. In vitro emulsification was assessed qualitatively after agitation using Pluronic F68 or a protein solution as the emulsion stabilizer. The addition of high-molecular-weight polymer increased the extensional viscosity of the blends at high strain rates to levels equal to or greater than silicone oil 5,000. In all cases, the shear viscosity of the blends was lower than that of silicone oil 5,000. The additive blends were qualitatively as emulsification-resistant as silicone oil 5,000. The addition of low concentrations of very-high-mole...Continue Reading

References

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Citations

Feb 3, 2012·Retina·Mario R RomanoJose L Vallejo-Garcia
Apr 4, 2013·Retina·Mario R RomanoPaolo Vinciguerra
Dec 4, 2009·The British Journal of Ophthalmology·Albert CaramoyBernd Kirchhof
Jul 12, 2014·BioMed Research International·Francesco BarcaStanislao Rizzo
Nov 25, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yau Kei ChanDavid Wong
Oct 18, 2014·Seminars in Ophthalmology·John B MillerDemetrios G Vavvas
Aug 13, 2014·BioMed Research International·Francesco MorescalchiFrancesco Semeraro
Mar 15, 2015·Journal of Biomaterials Applications·Albert CaramoyRachel L Williams
May 27, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Vincent J SolerVéronique Pagot-Mathis
Jan 27, 2018·International Journal of Retina and Vitreous·Shira Sheen-OphirAlexander Rubowitz
May 14, 2020·Ophthalmology and Therapy·Cláudia Oliveira-FerreiraAmândio Rocha-Sousa
Jun 24, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·David H W SteelTaiji Sakamoto
May 27, 2021·Eye·Mario R RomanoRodolfo Repetto
Nov 14, 2021·Journal of Biomechanical Engineering·Ru WangD Ian Wilson

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