PMID: 9176078Apr 1, 1997Paper

Increasing the intestinal resistance of rats to the invasive pathogen Salmonella enteritidis: additive effects of dietary lactulose and calcium

Gut
I M Bovee-OudenhovenR Van der Meer

Abstract

Lactulose fermentation by the intestinal microflora acidifies the gut contents, resulting in an increased resistance to colonisation by acid sensitive pathogens. The extent of fermentation should be controlled to prevent acid induced epithelial cell damage. Considering the buffering capacity of calcium phosphate and its intestinal cytoprotective effects, whether supplemental calcium phosphate adds to the increased resistance to intestinal infections by lactulose fermentations was studied. In a strictly controlled experiment, rats were fed a purified low calcium control diet, a low calcium/lactulose diet, or a high calcium/lactulose diet, and subsequently infected orally with Salmonella enteritidis. Lactulose fermentation lowered the pH and increased the lactic acid concentration of the intestinal contents, which significantly reduced excretion of this pathogen in faeces; thus it improved the resistance to colonisation. This agreed with the high sensitivity of S enteritidis to lactic acid (main metabolite of lactulose fermentation) in vitro. Calcium phosphate decreased translocation of S enteritidis to the systemic circulation, an effect independent of lactulose. The unfavourable increased cytotoxicity of faecal water caused by ...Continue Reading

Citations

Jan 23, 2009·Digestive Diseases and Sciences·Marleen T J van AmptingIngeborg M J Bovee-Oudenhoven
Mar 8, 2008·Bioscience, Biotechnology, and Biochemistry·Tatsuya MoritaShuhachi Kiriyama
Apr 1, 2010·Journal of Nutritional Science and Vitaminology·Yukako OkazakiNorihisa Kato
Mar 24, 2012·Animal : an International Journal of Animal Bioscience·S MasanetzM W Pfaffl
May 13, 2010·European Journal of Gastroenterology & Hepatology·Henrike M HamerRobert-Jan M Brummer
Sep 30, 2010·The British Journal of Nutrition·Sandra J M Ten BruggencateIngeborg M J Bovee-Oudenhoven
Oct 13, 1998·Alimentary Pharmacology & Therapeutics·S J Lewis, A R Freedman
Aug 29, 2002·Alimentary Pharmacology & Therapeutics·A Szilagyi
Feb 14, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·H M HamerR J Brummer
Mar 12, 2015·Journal of Clinical Biochemistry and Nutrition·Risa TairaToshio Taira
Jul 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Noortje IjssennaggerRoelof van der Meer
Jul 29, 2016·Journal of Nutritional Science and Vitaminology·Yukako OkazakiNorihisa Kato
Sep 16, 2017·Nutrients·Paulina Markowiak, Katarzyna Śliżewska
May 2, 2018·Journal of Nutritional Science and Vitaminology·Dwi Eva NirmagustinaNorihisa Kato
Nov 26, 2008·World Journal of Gastroenterology : WJG·Xiao-Ming BenXiao-Yu Zhou
Jul 17, 2009·The Journal of Nutrition·Hiroyuki ItoTatsuya Morita
Jul 5, 2019·Animal Science Journal = Nihon Chikusan Gakkaihō·Prabhu BalanPaul J Moughan
Dec 1, 2000·Applied and Environmental Microbiology·R C SprongR van Der Meer

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