PMID: 3770032May 1, 1986Paper

Increasing the thermosensitivity of a mammary tumor (CA755) through dietary modification

European Journal of Cancer & Clinical Oncology
J A ElegbedeM B Yatvin

Abstract

Disruption of the integrity of tumor cellular membranes has been proposed as an initiating event in hyperthermic cell death. Thermosensitivity measured by the shift in the harmonic mean of tumor regrowth delay of CA755 mammary adenocarcinomas grown in the hind legs of male BDF1, mice increased 22% when the hosts were fed a diet enriched in polyunsaturated fatty acids. Although the diet elicited the anticipated increase in tumor membrane phospholipid polyunsaturated fatty acids, the proportion of total unsaturated fatty acids decreased and the proportion of membrane-rigidifying saturated fatty acids increased. Concomitantly, the concentrations of cholesterol and phospholipid phosphorus increased and the ratio of phosphatidylethanolamine to phosphatidylcholine decreased, presumably to counter the effect of the change in the fatty acid pattern. In host liver membranes, the diet-mediated increase in proportion of polyunsaturated fatty acids was not accompanied by an increase in the proportion of rigidifying saturated fatty acids. Instead, the homeoviscous adaptation consisted of decreases in monounsaturated fatty acids and cholesterol concentration and an increase in the phosphatidylethanolamine-phosphatidylcholine ratio. Addition ...Continue Reading

References

Dec 1, 1977·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·M B Yatvin
Sep 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·S E Carlson, S Goldfarb
Feb 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M Sinensky
Mar 16, 1971·Biochimica Et Biophysica Acta·A MontfoortL L van Deenen
Apr 1, 1983·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·A M GeorgeW A Cramp
May 1, 1983·European Journal of Cancer & Clinical Oncology·M B YatvinC E Elson
Apr 1, 1984·Atherosclerosis·W C BurgerC E Elson
May 1, 1980·The Journal of Clinical Investigation·A A SpectorJ B Smith
Jan 1, 1981·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R T MulcahyM B Yatvin
May 1, 1980·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·M B YatvinW H Dennis
Mar 1, 1981·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·W H Dennis, M B Yatvin
Jan 1, 1981·The Biochemical Journal·S M Innis, M T Clandinin

❮ Previous
Next ❯

Citations

Dec 1, 1988·Mechanisms of Ageing and Development·J H KimE Shrago
Jan 1, 1987·Radiation and Environmental Biophysics·M B YatvinC E Elson
Apr 24, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yogita K Adlakha, Neeru Saini
Oct 1, 1988·European Journal of Cancer & Clinical Oncology·O R MongeO Kaalhus
Mar 1, 1993·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M B Yatvin, W A Cramp
Aug 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·M Harms-RingdahlC Vaca
Feb 1, 1989·International Journal of Radiation Biology·M Harms-RingdahlC Vaca
Jun 1, 1990·Nutrition Reviews·C P Burns, A A Spector
Aug 28, 2014·Journal of Proteome Research·Hai JinXianfu Gao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.