Increasing underrepresentation of elderly patients with advanced colorectal or non-small-cell lung cancer in chemotherapy trials

Internal Medicine Journal
R R JennensR M Fox

Abstract

Elderly patients are underrepresented in chemotherapy trials for advanced colorectal cancer (CRC) and non-small-cell lung cancer (NSCLC). However, the change in underrepresentation over time has not been documented. This study aimed to quantify (i) the change in the median age of patients enrolled in clinical trials for metastatic CRC and NSCLC between 1982-1991 and 1992-2001 compared with the general colorectal and lung cancer population, and (ii) the proportion of trials with an upper age limit for eligibility. A retrospective review of data from the Victorian Cancer Registry and all large published randomized chemotherapy trials for advanced CRC and NSCLC between 1982 and 2001 was conducted. The median age of patients with CRC enrolled in clinical trials remained constant between the two decades (62.0 and 62.2 years), whereas the median age of the CRC population increased from 68.4 to 70.2 years, increasing the median age difference from 6.4 to 8.0 years. The median age of patients with lung cancer in clinical trials increased from 59.8 to 61.8 years, whereas the median age of the lung cancer population increased from 67.4 to 70.4 years, widening the age difference from 7.6 to 8.6 years. More trials set an upper age limit fo...Continue Reading

References

Oct 1, 1994·Cancer·E L TrimbleM A Friedman
Dec 30, 1999·The New England Journal of Medicine·L F HutchinsK S Albain
Aug 17, 2000·British Journal of Cancer·G D BerettaR Labianca
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C C EarleJ C Weeks
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Warren B SaterenMichaele C Christian
May 25, 2002·ANZ Journal of Surgery·John A McLeishGraham G Giles
Feb 6, 2003·Cancer·Hongbin ChenMartine Extermann
Mar 1, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Martin WeinmannMichael Bamberg
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karen W L YeeLillian L Siu
Dec 4, 2003·Cancer Control : Journal of the Moffitt Cancer Center·Stuart M Lichtman
Jan 30, 2004·Salud pública de México·Silvina ArrossiDonald Maxwell Parkin
Apr 22, 2006·ANZ Journal of Surgery·Jeremy L MillarUNKNOWN Urology Study Committee of the Victorian Co-operative Oncology Group

❮ Previous
Next ❯

Citations

Apr 6, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·M T E PutsA E Tourangeau
Oct 7, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M T E PutsH Bergman
Nov 9, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A TamiyaI Kawase
Sep 4, 2012·Therapeutic Advances in Medical Oncology·Elisabeth Quoix
Dec 30, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth A ChrischillesRobert H Fletcher
Mar 20, 2008·World Journal of Gastroenterology : WJG·Gerardo Rosati, Domenico Bilancia
Jun 24, 2010·Revue des maladies respiratoires·E QuoixUNKNOWN l'Intergroupe francophone de cancérologie thoracique (IFCT)
Mar 19, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A G PallisM O'Brien
Mar 11, 2011·La Presse médicale·Elisabeth QuoixPhilippe Fraisse
Nov 26, 2008·Seminars in Oncology·Nilesh Vora, Karen L Reckamp
Oct 24, 2008·Alimentary Pharmacology & Therapeutics·E Mitry, P Rougier
Nov 11, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Viktoria VolkUlrich Mey
Apr 14, 2015·Asia-Pacific Journal of Clinical Oncology·Sumitra AnandaPeter Gibbs
Jun 8, 2015·Breast Cancer Research and Treatment·Megan E V CaramJennifer J Griggs
Mar 24, 2015·Expert Opinion on Pharmacotherapy·Bianca A M H van VeggelEgbert F Smit
May 13, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J SastreUNKNOWN Spanish Cooperative Group for the Treatment of Digestive Tumours TTD
May 6, 2015·Oncoimmunology·Ming-Ching LeePrasad S Adusumilli
Dec 4, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·S K Vinod
Sep 7, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Elisabeth QuoixBernard Milleron
May 24, 2016·Clinical Oncology : a Journal of the Royal College of Radiologists·K J DugganS K Vinod
Jun 9, 2016·Journal of Geriatric Oncology·Ravindran KanesvaranLalit Krishna
Nov 4, 2016·Lung·Karlijn J G SchulkesMarije E Hamaker
Jul 8, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Rinus WandersDirk De Ruysscher
Dec 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Taofeek K OwonikokoSuresh S Ramalingam
Jan 15, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Taofeek K Owonikoko, Suresh S Ramalingam
Mar 28, 2017·PloS One·Floor J van DeudekomSimon P Mooijaart
Jan 16, 2020·PloS One·E-Shien ChangBecca R Levy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved