Increment of serum C-peptide measured by glucagon test closely correlates with human relative beta-cell area

Endocrine Journal
Yukari FujitaIichiro Shimomura

Abstract

Pancreatic beta-cell mass contributes to glucose tolerance. The aim of this study was to evaluate the relationships between human beta-cell mass and various clinical parameters, including insulin secretory capacity. The study included 32 Japanese patients who underwent pancreatectomy and were naive to oral hypoglycemic agents and insulin. They were classified into those with normal glucose tolerance (n=13), impaired glucose tolerance (n=9) and diabetes (n=10), and their insulin secretory capacity and insulin resistance were evaluated. Immunohistochemistry was used to determine relative beta-cell area (%) which represented the proportion of insulin-positive cell area to whole pancreatic section. Increment of C-peptide immunoreactivity level by glucagon test (ΔC-peptide, increment of serum C-peptide [nmol/L] at 6 min after intravenous injection of 1-mg glucagon; r=0.64, p=0.002), homeostasis model assessment of beta-cell function (HOMA-beta, fasting immunoreactive insulin [μIU/mL] x 20 / (fasting plasma glucose [mmol/L] - 3.5); r=0.50, p=0.003), C-peptide index (CPI, fasting C-peptide [nmol/L] / fasting plasma glucose [mmol/L]; r=0.36, p=0.042), and fasting immunoreactive insulin (F-IRI [pmol/L]; r=0.36, p=0.044) correlated signi...Continue Reading

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Citations

Mar 24, 2018·Journal of Diabetes Investigation·Yukari FujitaIichiro Shimomura
Apr 12, 2016·Journal of Animal Science·M A de LaatM N Sillence
Mar 20, 2020·Journal of the Endocrine Society·Harutoshi OzawaIichiro Shimomura
Aug 19, 2021·Journal of the Endocrine Society·Hironobu SasakiHiroshi Itoh
Dec 26, 2021·BMJ Open Diabetes Research & Care·Harutoshi OzawaIichiro Shimomura

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