Incremental value of PET/CT Over CT for mediastinal nodal staging of non-small cell lung cancer: Comparison between patients with and without idiopathic pulmonary fibrosis

AJR. American Journal of Roentgenology
Tae Yeon JeonYoung Mog Shim

Abstract

We aimed to compare the incremental value of FDG PET/CT over CT for the assessment of mediastinal nodal status between patients with non-small cell lung cancer (NSCLC) and idiopathic pulmonary fibrosis (IPF) and those with NSCLC but without IPF. Forty-two patients with NSCLC and IPF (mean age, 66 years) were matched to 168 patients with NSCLC but without IPF (mean age, 65 years). Patients underwent surgical mediastinal nodal staging after both integrated PET/CT and contrast-enhanced CT scans had been obtained. Histopathologic nodal assessment served as the reference standard. PET/CT had better specificity (91% [29/32 patients] vs 47% [15/32]; p = 0.0002) and accuracy (83% [35/42] vs 50% [21/42]; p = 0.001) than CT did in patients with IPF. In patients without IPF, PET/CT was better than CT alone with regard to sensitivity (62% [26/42] vs 40% [17/42]; p = 0.0067), specificity (96% [121/126] vs 84% [106/126]; p = 0.0002), and accuracy (88% [147/168] vs 73% [123/168]; p < 0.0001). Thus, the incremental accuracy of PET/CT, which was 33% (14/42) for patients with IPF and 14% (24/168) for patients without IPF (p = 0.0041), was mainly the result of improved specificity. PET/CT offers significantly increased accuracy versus CT in media...Continue Reading

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Citations

Nov 29, 2012·General Thoracic and Cardiovascular Surgery·Atsushi WatanabeTetsuya Higami
Oct 7, 2011·Advances in Therapy·Oisin J O'ConnellMichael T Henry
Jun 26, 2013·AJR. American Journal of Roentgenology·Diane C StrolloMaria M Crespo
May 12, 2012·Journal of Biomedicine & Biotechnology·Fangfang Chao, Hong Zhang
Apr 5, 2011·European Journal of Radiology·Valentina AmbrosiniStefano Fanti
Nov 14, 2014·The Cochrane Database of Systematic Reviews·Mia Schmidt-HansenMarta Roqué I Figuls

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