Incremental value of subclinical left ventricular systolic dysfunction for the identification of patients with obstructive coronary artery disease

American Heart Journal
Gaetano NuciforaJeroen J Bax

Abstract

Left ventricular (LV) diastolic dysfunction and subclinical systolic dysfunction may be markers of coronary artery disease (CAD). However, whether these markers are useful for prediction of obstructive CAD is unknown. A total of 182 consecutive outpatients (54 +/- 10 years, 59% males) without known CAD and overt LV systolic dysfunction underwent 64-slice multislice computed tomography (MSCT) coronary angiography and echocardiography. The MSCT angiograms showing atherosclerosis were classified as showing obstructive (> or =50% luminal narrowing) CAD or not. Conventional echocardiographic parameters of LV systolic and diastolic function were obtained; in addition, (1) global longitudinal strain (GLS) and strain rate (indices of systolic function) and (2) global strain rate during the isovolumic relaxation period and during early diastolic filling (indices of diastolic function) were assessed using speckle-tracking echocardiography. In addition, the pretest likelihood of obstructive CAD was assessed using the Duke Clinical Score. Based on MSCT, 32% of patients were classified as having no CAD, whereas 33% showed nonobstructive CAD and the remaining 35% had obstructive CAD. Multivariate analysis of clinical and echocardiographic ch...Continue Reading

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Citations

Dec 15, 2011·European Heart Journal Cardiovascular Imaging·David E MontgomeryKofo O Ogunyankin
Mar 4, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Daniel A MorrisMasaaki Takeuchi
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May 9, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Kevin LiouSze-Yuan Ooi
Feb 16, 2018·Echocardiography·Christoffer E HagemannTor Biering-Sørensen
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Jan 15, 2021·The International Journal of Cardiovascular Imaging·C SciaccalugaM Focardi
Sep 10, 2021·The International Journal of Cardiovascular Imaging·Michal Laufer-PerlZach Rozenbaum

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