Abstract
To summarize evidence from and assess the quality of published systematic reviews evaluating the safety, efficacy and effectiveness of incretin-based medications used in the treatment of type 2 diabetes. We identified systematic reviews of randomized controlled trials or observational studies published in any language that evaluated the safety and/or effectiveness of glucagon-like peptide-1 (GLP-1) receptor agonists or dipeptidyl-peptidase-4 (DPP-4) inhibitors. Data sources used include the Cochrane Library, PubMed, EMBASE, Web of Science, International Pharmaceutical Abstracts, table of contents of diabetes journals, and hand-searching of reference lists and clinical practice guidelines. The methodological quality of systematic reviews was independently assessed by two reviewers using the Assessment of Multiple Systematic Reviews (AMSTAR) checklist. Our study protocol was registered with PROSPERO (2013:CRD42013005149). The primary outcomes were pooled treatment effect estimates for glycaemic control, macrovascular and microvascular complications, and hypoglycaemic events. We identified 467 unique citations of which 84 systematic reviews met our inclusion criteria. There were 51 reviews that evaluated GLP-1 receptor agonists an...Continue Reading
References
Jun 19, 2004·BMJ : British Medical Journal·David AtkinsUNKNOWN GRADE Working Group
Mar 29, 2007·PLoS Medicine·David MoherDouglas G Altman
Jan 30, 2008·Circulation·Silvio E Inzucchi, Darren K McGuire
Apr 1, 2008·Journal of Clinical Pathology·L R Ranganath
Jun 4, 2008·Annals of Internal Medicine·Susan L NorrisUNKNOWN U.S. Preventive Services Task Force
Feb 24, 2009·Journal of Clinical Epidemiology·Beverley J SheaMaarten Boers
Mar 25, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L MonastaJ Brug
Feb 5, 2011·BMC Medical Research Methodology·Valerie SmithMike Clarke
Mar 23, 2011·Journal of the American Medical Informatics Association : JAMIA·Monique W M JaspersLinda W Peute
May 6, 2011·Diabetes Care·Simona Cernea, Itamar Raz
May 18, 2011·Annals of Internal Medicine·Jorge L GrossUNKNOWN Diabetes and Endocrinology Meta-analysis Group (DEMA)
Jul 7, 2011·The Annals of Pharmacotherapy·Nicole R Pinelli, Kathryn M Hurren
Oct 26, 2011·Diabetes Care·Matteo MonamiEdoardo Mannucci
Jan 13, 2012·BMJ : British Medical Journal·Tina VilsbøllLise Lotte Gluud
Mar 20, 2012·The American Journal of Cardiology·Steven G Chrysant, George S Chrysant
Apr 11, 2012·Diabetes, Obesity & Metabolism·S-C LiuK-L Chien
Apr 21, 2012·Diabetes Care·Silvio E InzucchiUNKNOWN European Association for the Study of Diabetes (EASD)
Aug 30, 2012·BMC Medical Research Methodology·Hyun-Ju Seo, Kyeong Uoon Kim
Sep 22, 2012·Diabetes Care·Helena W Rodbard, Paul S Jellinger
Sep 22, 2012·Diabetes Care·Andrea GiaccariSimona Frontoni
Jan 29, 2013·BMJ Open·Louise E RobinsonJoseph P O'Hare
Jul 23, 2013·BMJ : British Medical Journal·Konstantinos C SiontisJohn P A Ioannidis
Sep 3, 2013·The New England Journal of Medicine·Benjamin M SciricaUNKNOWN SAVOR-TIMI 53 Steering Committee and Investigators
Sep 3, 2013·The New England Journal of Medicine·William B WhiteUNKNOWN EXAMINE Investigators
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Citations
Jan 18, 2017·Diabetes, Obesity & Metabolism·Manfredi RizzoGiorgio Sesti
Jun 21, 2016·PloS One·Hua V LinTianwei Ma
Apr 6, 2017·The Journal of Clinical Endocrinology and Metabolism·Tuuli SedmanVallo Volke
Jul 2, 2016·Medicine·John-Michael GambleSumit R Majumdar
Oct 6, 2015·Endocrinology and Metabolism·Eun Jung Rhee
Apr 16, 2016·Molecular Endocrinology·Oleg G ChepurnyColin A Leech
Jul 25, 2017·Diabetes Care·Muhammad Abdul-Ghani, Ralph A DeFronzo
Mar 14, 2019·Scientific Reports·Romain GirardFrançois Boudreau
Jan 25, 2018·Diabetes, Obesity & Metabolism·Sudesna ChatterjeeKamlesh Khunti
Oct 13, 2018·Scientific Reports·John-Michael GambleSumit R Majumdar
Dec 10, 2020·Sensors·Liu TangJen-Tsai Liu
Jun 12, 2021·Environmental Research·Fábio Hech DominskiAlexandro Andrade