Incretin-based therapies and renin-angiotensin system: Looking for new therapeutic potentials in the diabetic milieu

Life Sciences
Habib YaribeygiAmirhossein Sahebkar

Abstract

Incretin-based therapies include pharmacologic agents such as glucagon like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors which exert potent anti-hyperglycemic effects in the diabetic milieu. They are also shown to have extra-pancreatic effects. Renin-angiotensin system is part of the endocrine system which is widely distributed in the body and is closely involved in water and electrolyte homeostasis as well as renal and cardiovascular functions. Hence the renin-angiotensin system is the main target for treating patients with various renal and cardiovascular disorders. There is growing evidence that incretins have modulatory effects on renin-angiotensin system activity; thereby, can be promising therapeutic agents for the management of renal and cardiovascular disorders. But the exact molecular interactions between incretins and renin-angiotensin system are not clearly understood. In this current study, we have reviewed the possible molecular mechanisms by which incretins modulate renin-angiotensin system activity.

Citations

Apr 24, 2021·Scientific Reports·Mildred Fátima de la Luz Alvarez-CanalesRodolfo Guardado-Mendoza
May 20, 2021·Oxidative Medicine and Cellular Longevity·Habib YaribeygiAmirhossein Sahebkar
Jun 15, 2021·International Immunopharmacology·Shabnam RadbakhshAmirhossein Sahebkar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Related Papers

Contributions to Nephrology
Atsuhiro IchiharaL Gabriel Navar
Coeur et médecine interne
R Haïat, P Chiche
Pharmacological Reviews
W S Peart
South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
R Zamit
Nihon Jinzo Gakkai shi
Sadayoshi Ito
© 2022 Meta ULC. All rights reserved