Incretins, Diabetes, Pancreatitis and Pancreatic Cancer: What the GI specialist needs to know

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Chris E Forsmark

Abstract

There has been recent concern over the pancreatic safety of incretin-based therapies for diabetes. While drug-induced pancreatitis is a rare event, the large number of patients with diabetes make the potential impact of diabetic drugs significant. This review examines the relationship between diabetes, pancreatitis, and pancreatic cancer and the data assessing the potential impact of incretin-based therapies on these diseases. This narrative review assesses the current data assessing the potential role of incretin-based therapies causing pancreatitis or pancreatic cancer. Accompanying articles examine the role of incretin-based therapies in managing Type 2 diabetes, and the basic science studies examining the interaction of these drugs with the pancreas. There is a strong relationship between diabetes, pancreatitis, and pancreatic cancer. Diabetes is a risk factor for acute pancreatitis, and for pancreatic cancer. Chronic pancreatitis can cause diabetes, and is a risk factor for pancreatic cancer. Finally, pancreatic cancer can cause diabetes. These complex interactions make it difficult to sort out the potential impact of incretin-based therapies in these conditions. While early anecdotal reports identified a serious safety si...Continue Reading

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Citations

Feb 20, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·David Fine
Sep 23, 2016·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Han ChenGuoxin Zhang
Apr 5, 2019·Diabetes, Obesity & Metabolism·Donnie FunchDavid D Dore
Dec 4, 2019·BMJ : British Medical Journal·O Joe Hines, Stephen J Pandol
Jan 16, 2018·Expert Opinion on Drug Safety·Agostino ConsoliFabrizio Febo
Dec 14, 2016·The New England Journal of Medicine·Chris E ForsmarkC Mel Wilcox
Jun 27, 2019·Antioxidants·Filip VlavcheskiEvangelia Tsiani
Mar 30, 2020·Current Diabetes Reports·Gabriel Xavier Ramalho, Marcio Garrison Dytz
Mar 11, 2017·Digestive Diseases and Sciences·Mitchell L RamseyPhil A Hart
Jun 6, 2021·The Lancet. Gastroenterology & Hepatology·Phil A HartGeorgios I Papachristou
Jul 16, 2021·Current Opinion in Gastroenterology·Phil A HartMark O Goodarzi

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