PMID: 2122631Jan 1, 1990Paper

Incubation periods and histopathological changes in mice injected stereotaxically in different brain areas with the 87V scrapie strain

Acta Neuropathologica
Y S KimH M Wisniewski

Abstract

After stereotaxic injection into five different brain areas (cortex, caudate nucleus, substantia nigra, thalamus and cerebellum) of IM mice with the 87V scrapie strain, the cerebellum had the shortest incubation period. The vacuolation pattern was similar regardless of the area injected with extensive vacuolation in the thalamus, mesencephalon and hypothalamus. The pattern of amyloid plaques differed markedly depending on the area injected. In particular, no plaques were seen anywhere in the brain after injection into intact cerebellum, whereas injection into the four cerebral areas yielded plaques in the forebrain but not in the cerebellum. The incubation period after injection into bisected cerebella was much longer than after injection into intact cerebella. Mice injected on one side of bisected cerebellum had amyloid plaques in the forebrain but not in the cerebellum. There is a discussion of the finding that, although no plaques and virtually no vacuolation were seen in the cerebellum, the shortest incubation period occurred after injection into intact cerebellum.

References

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Citations

Jan 1, 1994·Archives of Virology·R I CarpP D Mehta
Dec 10, 2002·Mechanisms of Ageing and Development·Kwon HurYong-Sun Kim
Aug 29, 2000·Neuroscience Letters·Y G ChoiY S Kim
Feb 15, 2011·Veterinary Research·Carmen SerranoInmaculada Martín-Burriel
May 18, 1999·Molecular and Chemical Neuropathology·S W YunY S Kim
Apr 10, 2012·Veterinary Microbiology·Carlos HedmanRosa Bolea
Jan 9, 2016·Veterinary Research·Carlos HedmanJuan José Badiola
Nov 28, 2015·The Journal of General Virology·Lorenzo GonzálezMartin Jeffrey
Oct 24, 2007·Brain Research·Jaber LyahyaiInmaculada Martín-Burriel
Apr 5, 2019·Journal of Veterinary Science·Joshua Adekunle BabalolaYong-Sun Kim
Jul 10, 1999·Free Radical Research·D W LeeH M Wisniewski
Aug 5, 2004·Journal of Neuropathology and Experimental Neurology·Marcin SadowskiThomas Wisniewski

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