Indacaterol maleate for the treatment of chronic obstructive pulmonary disease

Expert Opinion on Pharmacotherapy
Donald P Tashkin

Abstract

Chronic obstructive pulmonary disease (COPD) is a partially reversible, progressive obstructive disorder. Bronchodilators are the mainstay of treatment since they improve lung function and patient-reported outcomes and reduce acute exacerbations. Long-acting inhaled bronchodilators (at present including the once-daily antimuscarinic tiotropium, and the twice-daily beta(2)-agonists formoterol and salmeterol) are recommended as first-line treatment for patients with persistent symptoms. Indacaterol maleate has been developed as a new once-daily inhaled beta(2)-selective agonist. This article reviews the published literature on the pharmacologic properties and the Phase II and III trials that have evaluated the safety and efficacy of this new agent. The reader will obtain an appreciation of the safety and efficacy of indacaterol and the role that it might play in the future management of COPD of varying severity. Indacaterol is a new, once-daily beta(2)-agonist with an onset of action within 5 min and a duration of bronchodilation of at least 24 h. In doses of 150 and 300 microg, it has sustained benefits over 6 - 12 months with respect to both bronchodilation and patient-reported outcomes and is well-tolerated with an acceptable ...Continue Reading

References

Dec 1, 2006·The European Respiratory Journal·E NalineM Molimard
Feb 21, 2007·Annals of Internal Medicine·Shawn D AaronUNKNOWN Canadian Thoracic Society/Canadian Respiratory Clinical Research Consortium
Feb 23, 2007·The New England Journal of Medicine·Peter M A CalverleyUNKNOWN TORCH investigators
May 25, 2007·The New England Journal of Medicine·Peter J Barnes
May 21, 2008·International Journal of Chronic Obstructive Pulmonary Disease·Roberto Dal Negro
Oct 7, 2008·The New England Journal of Medicine·Donald P TashkinUNKNOWN UPLIFT Study Investigators
May 26, 2009·Pulmonary Pharmacology & Therapeutics·J BeierS Pascoe
Jul 14, 2009·Chest·Bartolome CelliDonald P Tashkin
Aug 1, 2009·American Journal of Respiratory and Critical Care Medicine·Tobias WelteRomain Kessler
Jan 19, 2010·Pulmonary Pharmacology & Therapeutics·Peter J BarnesDavid Lawrence

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Citations

Feb 9, 2012·Lancet·Marc DecramerMarc Miravitlles

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