Indapamide and atenolol in the treatment of hypertension: double-blind comparative and combination study

Current Medical Research and Opinion
O De DivitiisV Ligouri

Abstract

Fifteen out-patients with moderate hypertension were randomly and sequentially treated with atenolol, indapamide and a combination of the two drugs after a wash-out period of at least 1 week and a 2-week placebo run-in period. The duration of treatment was 4 weeks in each case. The dosage was 2.5 mg indapamide and 100 mg atenolol, in single tablets which were taken at 11.00 hours. All the treatment regimens produced a highly significant (p less than 0.001) reduction in systolic and diastolic, supine and standing blood pressure; these reductions were not significantly different for the single drugs but were significantly greater for the combined therapy. The number of patients reaching the end-point of a diastolic blood pressure of 95 mmHg or less was the same with either atenolol or indapamide, i.e. 7 (46.6%), but was greater with the combined therapy, i.e. 10 (66.6%). A significant (p less than 0.001) reduction in pulse rate was observed with the treatments involving atenolol. Acceptability of the treatments was very good; the number of volunteered and elicited complaints during the different treatments being less compared to the placebo period, particularly for the combined treatment. No significant difference was observed in...Continue Reading

References

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Citations

Oct 13, 2009·The Cochrane Database of Systematic Reviews·Jenny Mh ChenJames M Wright
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Jenny Mh ChenJames M Wright
Nov 1, 1995·The Annals of Pharmacotherapy·T Y Chan

Related Concepts

Tenormin
Clinical Trials
Diuretic Effect
Double-Blind Method
Polychemotherapy
Hypertensive Disease
S-1520
Randomization

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