PMID: 3767542Oct 1, 1986Paper

Indapamide. Effects on apoprotein, lipoprotein, and glucoregulation in ambulatory diabetic patients

Archives of Internal Medicine
K OseiJ M Falko

Abstract

We evaluated the long-term effects of indapamide, a non-thiazide diuretic, on blood pressure, glucoregulation, free insulin and C-peptide levels, and lipoprotein and apoprotein metabolism in 13 hypertensive diabetic patients for 24 weeks. Indapamide significantly reduced both systolic and diastolic blood pressure by 15% and 17%, respectively. Both mean fasting serum glucose and integrated glucose responses after oral glucose load (75 g) were significantly higher during indapamide therapy than at week 0. The mean fasting and stimulated C-peptide responses were significantly increased despite worsening glucose control. At the end of 24 weeks, mean glycosylated hemoglobin level had increased significantly. Indapamide caused a slight but insignificant rise in the total triglyceride, cholesterol, and low-density lipoprotein cholesterol levels, while the high-density lipoprotein cholesterol level decreased. In addition, the apoprotein A-1 concentrations remained unchanged while the apoprotein B-100 level decreased. Apart from hypokalemia (less than 3.5 mEq/L [less than 3.5 mmol/L]) in three patients that required oral potassium supplementation, biochemical changes were of no clinical consequence.

Citations

Feb 1, 1990·Journal of Clinical Pharmacology·L M PrisantC G Hames
May 1, 1988·Baillière's Clinical Endocrinology and Metabolism·P L Drury
Aug 28, 2004·Diabetes Research and Clinical Practice·Zhang Jian-LiangXu Rong-Liang
May 23, 2002·Current Medical Research and Opinion·Apostolos AchimastosMoses Elisaf

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