Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden on Cognitive Function in Mild Cognitive Impairment

Journal of Korean Medical Science
Eun Hyun SeoAlzheimer's Disease Neuroimaging Initiative

Abstract

This study aimed to investigate the independent and interactive influences of apolipoprotein E (APOE) ε4 and beta-amyloid (Aβ) on multiple cognitive domains in a large group of cognitively normal (CN) individuals and patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Participants were included if clinical and cognitive assessments, amyloid imaging, and APOE genotype were all available from the Alzheimer's Disease Neuroimaging Initiative database (CN = 324, MCI = 502, AD = 182). Individuals with one or two copies of ε4 were designated as APOE ε4 carriers (ε4+); individuals with no ε4 were designated as APOE ε4 non-carriers (ε4-). Based on mean florbetapir standard uptake value ratios, participants were classified as Aβ burden-positive (Aβ+) or Aβ burden-negative (Aβ-). In MCI, APOE ε4 effects were predominantly observed on frontal executive function, with ε4+ participants exhibiting poorer performances; Aβ positivity had no influence on this effect. Aβ effects were observed on global cognition, memory, and visuospatial ability, with Aβ+ participants exhibiting poorer performances. Measures of frontal executive function were not influenced by Aβ. Interactive effects of APOE ε4+ and Aβ were observed on glo...Continue Reading

References

Aug 17, 2000·The New England Journal of Medicine·S Y BookheimerG W Small
Apr 12, 2003·Neurology·P BretskyUNKNOWN MacArthur Studies of Successful Aging
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Nov 14, 2008·Neurobiology of Aging·Fan LiuCornelia M van Duijn
Mar 17, 2009·Neurobiology of Aging·Nick M WisdomKeith A Hawkins
Apr 3, 2009·Brain : a Journal of Neurology·Clifford R JackUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 29, 2009·Annals of Neurology·David A WolkSteven T De-Kosky
Jul 17, 2009·The New England Journal of Medicine·Richard J CaselliEric M Reiman
Nov 13, 2009·Neuropsychology Review·Karen M RodrigueDenise C Park
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
May 11, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Andrew J SaykinUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·David A WolkUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 23, 2010·NeuroImage·Hwamee OhWilliam J Jagust
Oct 6, 2011·Journal of Alzheimer's Disease : JAD·Christine Fennema-NotestineWilliam S Kremen
May 31, 2012·Brain Imaging and Behavior·Laura E GibbonsUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 12, 2012·Brain Imaging and Behavior·Paul K CraneUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 11, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Agneta NordbergKarl Herholz
Oct 17, 2012·Neurology·Yen Ying LimUNKNOWN AIBL Research Group
Oct 31, 2012·Annals of Neurology·Susan M LandauUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 31, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Yu-Ling ChangUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 2, 2013·Brain : a Journal of Neurology·Yen Ying LimUNKNOWN AIBL Research Group
Jan 24, 2014·Neurology·Geoffrey A KerchnerBrian K Rutt
Mar 5, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Yen Ying LimChristopher C Rowe
Mar 13, 2014·Journal of Internal Medicine·R C PetersenL Fratiglioni
Mar 22, 2014·Neuroscience Bulletin·Evan DoreyWandong Zhang
May 20, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Ying LiuLan Tan

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Citations

Aug 29, 2016·Journal of Alzheimer's Disease : JAD·Eun Hyun SeoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Dec 19, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M BaUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 16, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Dallas P VeitchUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 4, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Walter E MüllerHans-Jürgen Möller

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