Abstract
Recent studies have reported no association between elevated glycated hemoglobin (HbA(1c)) and incident cardiovascular disease (CVD) among women without diabetes. This study describes associations between HbA(1c) and new onset CVD in a representative adult population cohort. Assessment of participants in The North West Adelaide Health Study (NWAHS), a population study of randomly selected adults (age > or =18 years, n = 4,060), included measurement of height, weight, blood pressure, fasting lipids, glucose, and HbA(1c). A self-completed questionnaire assessed doctor-diagnosed diabetes, CVD and stroke, smoking status, and demographics. The cohort was followed for an average 3.5 years. Of the 2,913 adults free of diabetes at baseline and follow-up, 94 (3.5%) reported new onset coronary heart disease (CHD) and/or stroke. Compared with those with an HbA(1c) < or =5.0%, risk of new onset CVD was increased in those with HbA(1c) 5.4-5.6% (odds ratio (OR) 2.5, 95% confidence interval (CI) 1.4, 4.6), and > or =5.7% (OR 1.9, 95% CI 1.1, 3.4), after adjustment for other risk factors. The association was stronger in women than men (P = 0.03), and attenuated to only a small degree by addition of impaired fasting glucose (IFG), hypertension,...Continue Reading
References
Jul 1, 1995·Annals of Epidemiology·D G IvesS Theroux
May 1, 1996·Diabetes Care·S ParkS Edelstein
May 29, 1998·Circulation·P W WilsonW B Kannel
Sep 23, 1998·Australian and New Zealand Journal of Public Health·A W TaylorM Wakefield
May 20, 1999·Diabetes Care·M CoutinhoS Yusuf
Jul 28, 1999·Clinical and Experimental Hypertension : CHE·J ChalmersT Clark
Sep 3, 1999·BMJ : British Medical Journal·L E RamsayG Russell
Mar 14, 2000·Nursing Outlook·K J BurnsC T Chatterton
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·T EngstadM Viitanen
Aug 11, 2000·BMJ : British Medical Journal·I M StrattonR R Holman
Jun 14, 2002·Diabetes Research and Clinical Practice·David W DunstanUNKNOWN Australian Diabetes, Obesity and Lifestyle Study (AusDiab)
Sep 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·N UnwinK G M M Alberti
Nov 30, 2002·BMJ : British Medical Journal·Francesco P CappuccioSally M Kerry
Jan 31, 2003·The New England Journal of Medicine·Peter GaedeOluf Pedersen
Feb 18, 2003·Archives of Internal Medicine·Yong-Woo ParkSteven B Heymsfield
Aug 2, 2003·Sozial- Und Präventivmedizin·Tiffany GillPatrick Phillips
Apr 14, 2004·Archives of Internal Medicine·Gavin J BlakeRobert J Glynn
Apr 22, 2004·JAMA : the Journal of the American Medical Association·Ferdinando C SassoDomenico Cozzolino
Jul 14, 2004·Circulation·Scott M GrundyUNKNOWN American Heart Association
Sep 11, 2004·Journal of the American College of Cardiology·Scott M GrundyUNKNOWN Coordinating Committee of the National Cholesterol Education Program
Sep 24, 2004·Annals of Internal Medicine·Kay-Tee KhawNicholas Day
Oct 27, 2004·Archives of Internal Medicine·Emily B LevitanSimin Liu
Nov 6, 2004·Journal of Clinical Epidemiology·Yuji OkuraRichard J Rodeheffer
Dec 8, 2004·American Journal of Epidemiology·Susan R HeckbertJ David Curb
Jul 27, 2005·Diabetes Care·Elizabeth SelvinUNKNOWN Atherosclerosis risk in communities study
Sep 15, 2005·Archives of Internal Medicine·Elizabeth SelvinMichael W Steffes
Nov 22, 2005·Lancet Neurology·Elizabeth SelvinA Richey Sharrett
Dec 24, 2005·BMJ : British Medical Journal·Rachel HuxleyMark Woodward
Apr 13, 2006·Epidemiologic Perspectives & Innovations : EP+I·Janet F GrantUNKNOWN North West Adelaide Health Study Team
Jun 20, 2007·Circulation·Elizabeth L M BarrJonathan E Shaw
Jul 21, 2007·Heart·M O'FlahertyS Capewell
Sep 1, 2007·PLoS Medicine·Debbie A LawlorGeorge Davey Smith
Nov 27, 2007·Journal of the American College of Cardiology·Earl S Ford, Simon Capewell
Citations
Jun 9, 2012·BMJ : British Medical Journal·Meng LeeBruce Ovbiagele
Sep 21, 2013·Journal of Epidemiology and Community Health·S AlmoosawiA M Stephen
Oct 14, 2011·BMC Cardiovascular Disorders·Ruth MartíRafel Ramos
Jan 9, 2013·BMC Gastroenterology·Han MaYouming Li
Sep 28, 2010·Cardiovascular Diabetology·Alok K GuptaWilliam D Johnson
Jun 4, 2010·PLoS Medicine·Nadeem SarwarVilmundur Gudnason
Mar 23, 2012·PloS One·Harald Jörn SchneiderNele Friedrich
Nov 16, 2013·PloS One·Shuolin WuUNKNOWN Investigators for the Survey on Abnormal Glucose Regulation in Patients With Acute Stroke Across China ACROSS-China
Feb 12, 2014·Metabolic Syndrome and Related Disorders·Fangjian GuoW Timothy Garvey
Sep 3, 2014·Nature Reviews. Endocrinology·Majken K JensenKenneth J Mukamal
Jul 16, 2014·Annals of Human Biology·Alireza EsteghamatiManouchehr Nakhjavani
Jan 27, 2016·Diabetes Research and Clinical Practice·Sarah L AppletonRobert J Adams
Jul 24, 2010·Australian and New Zealand Journal of Public Health·Anne TaylorPatrick Phillips
Sep 16, 2015·Current Diabetes Reports·Leah E CahillMajken K Jensen
Mar 22, 2014·Neurological Research·Shuolin WuYongjun Wang
Jul 28, 2015·PeerJ·Laia OlivaMarià Alemany
Mar 23, 2013·Free Radical Biology & Medicine·A VlassopoulosE Combet
Dec 15, 2010·Journal of the American College of Cardiology·Philip GreenlandUNKNOWN American Heart Association
Dec 3, 2011·Journal of the American College of Cardiology·Saurav Chatterjee, Subhankar Maitra
Mar 21, 2012·Diabetes Care·Julie K BowerElizabeth Selvin
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Raffaella ComitatoFabio Virgili
Jul 24, 2013·Diabetes Care·Masaru SakuraiUNKNOWN NIPPON DATA90 Research Group
Sep 11, 2009·Current Opinion in Lipidology·Marek H Dominiczak
Jan 10, 2009·The Journal of Allergy and Clinical Immunology·Sarah L AppletonUNKNOWN North West Adelaide Cohort Health Study Team
Mar 30, 2013·Journal of the American Heart Association·Jennifer K PaiEric B Rimm
Nov 26, 2010·Circulation·Philip GreenlandUNKNOWN American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Nov 1, 2018·Diabetes/metabolism Research and Reviews·Teresa Vanessa FiorentinoGiorgio Sesti
Feb 23, 2011·Diabetologia·R Santos-OliveiraT R Einarson
Apr 1, 2016·European Heart Journal. Quality of Care & Clinical Outcomes·Aisha GoharHester den Ruijter
Jan 5, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Roberto LorbeerWolfgang Lieb
Apr 4, 2021·International Journal of Environmental Research and Public Health·Brad WipfliSaurabh S Thosar
Apr 28, 2021·Sports Medicine·James FramptonEdward S Chambers
May 16, 2020·Diabetes & Metabolic Syndrome·Ajay PatelIshwarlal Jialal