Independent Association of Severity of Muscle Weakness With Disability as Measured by the Health Assessment Questionnaire Disability Index in Scleroderma

Arthritis Care & Research
Julie J PaikLaura K Hummers

Abstract

To determine whether the presence and degree of muscle weakness in scleroderma is associated with disability. The study included a cohort of 1,718 scleroderma patients who had available data on muscle strength and disability. The primary independent variable was muscle weakness as defined by the maximum Medsger muscle severity score and the outcome was disability as measured by the last recorded Health Assessment Questionnaire disability index (HAQ DI) score. Univariate regression analyses were performed to assess the association of HAQ DI scores with the Medsger muscle severity score and other scleroderma characteristics. A multivariate regression analysis was performed to determine whether an association existed between the degree of muscle weakness and disability, while controlling for confounders. In 1,718 patients with scleroderma, 22.8% (392 of 1,718) had muscle weakness, as defined by a Medsger muscle severity score of ≥1. This subset was more likely than those without weakness to have diffuse cutaneous scleroderma (55.6% versus 35.1%; P < 0.0001), higher modified Rodnan skin thickness scores (mean ± SD 16.3 ± 13.7 versus 10.3 ± 10.6; P < 0.00001), shorter disease duration (mean ± SD 5.21 ± 6.75 versus 6.22 ± 7.67 years;...Continue Reading

References

Dec 1, 1992·Archives of Neurology·L Averbuch-HellerO Abramsky
Aug 1, 1968·Arthritis and Rheumatism·T A MedsgerJ W Vester
May 1, 1981·Arthritis and Rheumatism·S G WestO J Lawless
Feb 1, 1980·Arthritis and Rheumatism·J F FriesH R Holman
Sep 1, 1995·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·J L PooleP Spitz
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·J L HankinsonK B Fedan
Jul 2, 2003·Health and Quality of Life Outcomes·Bonnie Bruce, James F Fries
Aug 24, 2004·Clinical Rheumatology·Yoshihiro MimuraKunihiko Tamaki
Mar 17, 2006·Annals of the Rheumatic Diseases·D KhannaP J Clements
Sep 28, 2007·Annals of the New York Academy of Sciences·Brigitte RanqueLuc Mouthon
May 1, 1969·Annals of the Rheumatic Diseases·J M ThompsonM Johnson
Dec 5, 2008·Annals of the Rheumatic Diseases·B RanqueL Mouthon
Mar 22, 2014·Scandinavian Journal of Rheumatology·M JungUNKNOWN Canadian Scleroderma Research Group (CSRG)

❮ Previous
Next ❯

Citations

Dec 2, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Elizabeth HarrisonSimon Lal
Jul 24, 2012·Rheumatic Diseases Clinics of North America·Tuulikki SokkaNasim A Khan
Aug 28, 2018·Current Opinion in Rheumatology·Julie J Paik
May 26, 2017·Arthritis Care & Research·Julie J PaikAndrew L Mammen
May 26, 2018·Expert Review of Respiratory Medicine·Abraham Samuel BabuJonathan Myers
Mar 8, 2020·Neurology. Neuroimmunology and Neuroinflammation·Xavier Suárez-CalvetJordi Díaz-Manera
Jan 5, 2021·La Radiologia medica·Shivani AhlawatLaura M Fayad
Aug 23, 2016·Current Opinion in Rheumatology·Julie J Paik
Mar 26, 2021·Rinshō shinkeigaku = Clinical neurology·Shiori KikuchiNaoyuki Hasebe
Jun 20, 2021·Rheumatology·Valérie LeclairUNKNOWN Canadian Inflammatory Myopathy Study Group
Jan 4, 2022·Physiotherapy Theory and Practice·Nurten Gizem ToreAbdurrahman Tufan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.