PMID: 8589877Nov 1, 1995Paper

Independent autonomic modulation of the human sinus and AV nodes: evidence from beat-to-beat measurements of PR and PP intervals during sleep

Journal of Cardiovascular Electrophysiology
P Kowallik, M Meesmann

Abstract

Evidence from animal experiments indicates that the autonomic nervous system may influence the sinus (SA) and atrioventricular (AV) nodes differently. We investigated, therefore, whether there are spontaneous functional differences in the innervation of the SA and AV nodes in man. This study was performed in 10 healthy males (ages 21 to 26 years) during strict bed rest from 10 pm to 6 am. Three ECG leads were digitized on-line. PR and PP intervals were determined on a beat-to-beat basis off-line using a correlation algorithm with an accuracy of +/- 2 msec and were verified visually. During major body movements, there were sudden decreases in PP intervals of 36 to 827 msec (mean 335) for periods of 6 to 265 seconds (mean 24). During these phases of heart rate (HR) acceleration, PR intervals showed either concomitant shortening (9 to 30 msec), no change, or lengthening (6 to 25 msec). Furthermore, tonic changes in the PR interval occurred over 15-minute periods during which the range of PP intervals was constant. Additionally, recovery-adjusted PR interval (PR-b2/RP) and cycle length were negatively correlated for some periods, which confirmed independent autonomic effects on SA node and AV node. Beat-to-beat measurement of PR in...Continue Reading

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Citations

Jan 1, 2003·Medical & Biological Engineering & Computing·R ShouldiceW McNicholas
Sep 21, 2006·Bulletin of Experimental Biology and Medicine·N N AlipovV M Smirnov
Apr 12, 2003·Pacing and Clinical Electrophysiology : PACE·Dan WichterleMarek Malik
Nov 4, 2000·Journal of Cardiovascular Electrophysiology·P KowallikM Meesmann
Aug 22, 2009·IEEE Transactions on Bio-medical Engineering·Aline CabassonStéphane Bermon
Oct 12, 2005·Journal of Electrocardiology·Celso Mendoza-GonzálezManuel Cárdenas
Dec 17, 2003·Pacing and Clinical Electrophysiology : PACE·Andreas SchuchertThomas Meinertz
Mar 1, 2005·Pacing and Clinical Electrophysiology : PACE·Andreas SchuchertThomas Meinertz
Jul 5, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Mathias BaumertEugene Nalivaiko
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·D J ChristiniB B Lerman
May 6, 2004·Pacing and Clinical Electrophysiology : PACE·Gabriel VanerioPablo Fernàndez Banizi
Nov 14, 1998·The American Journal of Physiology·C BraunM Meesmann

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