PMID: 11345365May 10, 2001Paper

Independent contribution of myocardial perfusion defects to exercise capacity and heart rate recovery for prediction of all-cause mortality in patients with known or suspected coronary heart disease

Journal of the American College of Cardiology
L A DiazMichael S Lauer

Abstract

The goal of this study was to determine the value of thallium201 single photon emission computed tomography (SPECT) imaging for prediction of all-cause mortality when considered along with functional capacity and heart rate recovery. Myocardial perfusion defects identified by thallium201 SPECT imaging are predictive of cardiac events. Functional capacity and heart rate recovery are exercise measures that also have prognostic implications. We followed 7,163 consecutive adults referred for symptom-limited exercise thallium SPECT (mean age 60 +/- 10, 25% women) for 6.7 years. Using information theory, we identified a probable best model relating nuclear findings to outcome to calculate a prognostic nuclear score. There were 855 deaths. Intermediate- and high-risk prognostic nuclear scores were noted in 28% and 10% of patients. Compared with those with low-risk scans, patients with an intermediate-risk score were at increased risk for death (14% vs. 9%, hazard ratio: 1.67, 95% confidence interval [CI]: 1.44 to 1.95, p < 0.0001), while those with high-risk scores were at greater risk (24%, hazard ratio: 2.98, 95% CI: 2.49 to 3.56, p < 0.0001). In multivariable analyses that adjusted for clinical characteristics, functional capacity ...Continue Reading

References

Sep 29, 1991·The New England Journal of Medicine·D B MarkD B Pryor
Aug 1, 1996·The American Journal of Cardiology·M S LauerT H Marwick
Dec 31, 1997·Journal of the American College of Cardiology·P E SmanioG A Beller
Apr 16, 1998·American Heart Journal·T D MillerR J Gibbons
Nov 11, 1998·Journal of the American College of Cardiology·M S LauerT H Marwick
Dec 29, 1998·Annals of Internal Medicine·D M Lloyd-JonesD Levy
Feb 18, 1999·JAMA : the Journal of the American Medical Association·M S LauerT H Marwick
Jun 29, 1999·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·R L Eisner, R E Patterson
Sep 14, 1999·Journal of the American College of Cardiology·M S LauerE J Topol
Sep 24, 1999·JAMA : the Journal of the American Medical Association·J M KwokR J Gibbons
Oct 8, 1999·The New England Journal of Medicine·E E CalleC W Heath
Oct 28, 1999·The New England Journal of Medicine·C R ColeM S Lauer
Nov 5, 1999·JAMA : the Journal of the American Medical Association·M WeiS N Blair
Sep 16, 2000·JAMA : the Journal of the American Medical Association·E O NishimeM S Lauer

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Citations

May 8, 2004·European Journal of Nuclear Medicine and Molecular Imaging·S R UnderwoodUNKNOWN Royal College of Radiologists
Dec 8, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Takayuki MatsukiKazuaki Shimamoto
Apr 3, 2007·Herzschrittmachertherapie & Elektrophysiologie·C W Israel
Mar 31, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Leslee J Shaw, Ami E Iskandrian
Dec 14, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Michael S Lauer
Nov 21, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sarkis B Baghdasarian, Gary V Heller
Feb 5, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alan W AhlbergGary V Heller
Jun 6, 2002·Lancet·Raymond J Gibbons
Apr 17, 2002·Journal of the American College of Cardiology·Michael S LauerUNKNOWN American Heart Association
Jun 10, 2003·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gregory S Thomas, Michael I Miyamoto
Jul 29, 2006·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Ugo Corrà, Pantaleo Giannuzzi
Jan 7, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Shinji SatoMitsuru Majima
Apr 2, 2004·Annals of Family Medicine·Barbara P YawnPeter C Wollan
Nov 8, 2005·International Heart Journal·Mahmut Tuna KatircibasiHaldun Muderrisoglu
Jul 11, 2006·International Heart Journal·Tuba BilselKemal Yesilcimen
Feb 27, 2007·Vascular Health and Risk Management·Ding-Yu FeiKenneth A Kraft
Jul 2, 2014·Annals of the American Thoracic Society·Shiraz A NisarOmar A Minai
Jan 14, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Valeria CantoniAlberto Cuocolo
Jun 17, 2006·Journal of Electrocardiology·Michael S LauerJoseph M Starobin
Dec 6, 2005·Journal of Vascular Nursing : Official Publication of the Society for Peripheral Vascular Nursing·Roberta K OkaJohn P Cooke
Nov 14, 2015·JACC. Cardiovascular Imaging·Jamieson M Bourque, George A Beller
Nov 10, 2010·The American Journal of Cardiology·Andrew J MarshallAndrew D Kelion
Jan 30, 2013·Pacing and Clinical Electrophysiology : PACE·Ahmet YilmazRafet Dizman
Jan 16, 2007·Journal of the American College of Cardiology·Louise D MetzKirsten E Fleischmann
Jun 15, 2013·JACC. Cardiovascular Imaging·Gianluca PontoneMauro Pepi
Apr 29, 2006·American Heart Journal·Joel W HughesRichard Josephson
Feb 7, 2017·Annals of Medicine·Sae Young JaeBarry A Franklin
Apr 21, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Jonathan MyersVictor F Froelicher
Oct 1, 2003·Circulation·Daniel B Mark, Michael S Lauer
Mar 23, 2011·Circulation·Michael S Lauer
Nov 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Lauren L SmithGeorge E Billman
Aug 5, 2006·Medicine and Science in Sports and Exercise·Robert WolkBruce D Johnson
Aug 23, 2006·American Journal of Physical Medicine & Rehabilitation·Shyi-Kuen WuSen-Wei Tsai
Jan 19, 2008·Medicine and Science in Sports and Exercise·Karen M ChackoRaymond O Estacio

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