Independent contributions of fMRI familiarity and novelty effects to recognition memory and their stability across the adult lifespan

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Marianne de ChastelaineMichael D Rugg

Abstract

The impact of age on the neural correlates of familiarity-driven recognition memory has received relatively little attention. Here, the relationships between age, the neural correlates of familiarity, and memory performance were investigated using an associative recognition test in young, middle-aged and older participants. Test items comprised studied, rearranged (items studied on different trials) and new word pairs. fMRI 'familiarity effects' were operationalized as greater activity for studied test pairs incorrectly identified as 'rearranged' than for correctly rejected new pairs. The reverse contrast was employed to identify 'novelty' effects. Estimates of familiarity strength were slightly but significantly lower for the older relative to the younger group. With the exception of one region in dorsal medial prefrontal cortex, fMRI familiarity effects (which were identified in medial and lateral parietal cortex, dorsal medial and left lateral prefrontal cortex, and bilateral caudate among other regions) did not differ significantly with age. Age-invariant 'novelty effects' were identified in the anterior hippocampus and the perirhinal cortex. When entered into the same regression model, familiarity and novelty effects indep...Continue Reading

References

Oct 5, 2011·Journal of Experimental Psychology. Learning, Memory, and Cognition·Katherine M IngramJohn T Wixted

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Citations

Jan 25, 2020·Journal of Clinical and Experimental Neuropsychology·Claire LancasterChris Hinds
Aug 22, 2017·Frontiers in Human Neuroscience·Christopher R Madan
Aug 15, 2017·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Michael D Rugg, Danielle R King
Mar 10, 2019·Neuroscience and Biobehavioral Reviews·Christine BastinEmmanuel J Barbeau
Aug 23, 2021·Brain and Cognition·Mingzhu HouMichael D Rugg

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