Independent dose calculations for commissioning, quality assurance and dose reconstruction of PBS proton therapy

Physics in Medicine and Biology
G MeierAntony J Lomax

Abstract

Pencil beam scanning proton therapy allows the delivery of highly conformal dose distributions by delivering several thousand pencil beams. These beams have to be individually optimised and accurately delivered requiring a significant quality assurance workload. In this work we describe a toolkit for independent dose calculations developed at Paul Scherrer Institut which allows for dose reconstructions at several points in the treatment workflow. Quality assurance based on reconstructed dose distributions was shown to be favourable to pencil beam by pencil beam comparisons for the detection of delivery uncertainties and estimation of their effects. Furthermore the dose reconstructions were shown to have a sensitivity of the order of or higher than the measurements currently employed in the clinical verification procedures. The design of the independent dose calculation tool allows for a high modifiability of the dose calculation parameters (e.g. depth dose profiles, angular spatial distributions) allowing for a safe environment outside of the clinical treatment planning system for investigating the effect of such parameters on the resulting dose distributions and thus distinguishing between different contributions to measured d...Continue Reading

References

Jan 1, 1996·Physics in Medicine and Biology·U SchneiderA Lomax
Mar 11, 1999·Physics in Medicine and Biology·A Lomax
Apr 24, 2004·Zeitschrift für medizinische Physik·Eros PedroniGoran Kotle
Mar 31, 2005·Physics in Medicine and Biology·A TourovskyE Pedroni
Mar 31, 2007·International Journal of Radiation Oncology, Biology, Physics·Leah N McDermottBen J Mijnheer
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Aug 12, 2014·Physics in Medicine and Biology·C GomàS Safai

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Citations

Jun 23, 2016·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Antje-Christin KnopfJamie McClelland
Jan 24, 2019·Journal of Applied Clinical Medical Physics·Keisuke YasuiHiroyuki Ogino
Dec 13, 2018·Physics in Medicine and Biology·Carla WinterhalterSairos Safai
Jan 15, 2019·Physics in Medicine and Biology·Carla WinterhalterSairos Safai
Jul 17, 2018·Physics in Medicine and Biology·C WinterhalterS Safai
Oct 28, 2019·The British Journal of Radiology·Francesca AlbertiniAntony Lomax
Oct 1, 2016·International Journal of Particle Therapy·Chris BeltranNadia N Laack
Feb 6, 2017·Physics in Medicine and Biology·G MeierA J Lomax
Feb 7, 2017·Physics in Medicine and Biology·O ActisA Mayor
Feb 7, 2018·Physics in Medicine and Biology·Miriam KriegerYe Zhang
Dec 14, 2018·Physics in Medicine and Biology·Carla WinterhalterSairos Safai
Jul 18, 2019·Physics in Medicine and Biology·C BulaD Meer
Nov 7, 2017·Zeitschrift für medizinische Physik·Markus StockStanislav Vatnitsky
Oct 11, 2020·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Dominic MaesJatinder Saini
Sep 30, 2021·Physics in Medicine and Biology·Lena NenoffFrancesca Albertini
Oct 29, 2021·Physics in Medicine and Biology·Harald PaganettiBrian Winey

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