Jun 16, 2012

Independent effect of ethnicity on glycemia in South Asians and white Europeans

Diabetes Care
Samiul A MostafaKamlesh Khunti

Abstract

HbA(1c) levels are higher in most ethnic groups compared with white Europeans (WEs) independent of glycemic control. This comparison has not been performed between South Asians (SAs) and WEs. We analyzed the independent effect of ethnicity on HbA(1c) and fasting and 2-h plasma glucose (FPG and 2 hrPG, respectively) between these groups. Analysis of the ADDITION-Leicester study, in which 4,688 WEs and 1,352 SAs underwent oral glucose tolerance testing, HbA(1c), and other risk factor measurements. Significant associations with HbA(1c) included ethnicity, FPG, 2 hrPG, and homeostasis model assessment of β-cell function (P < 0.001); age and sex (P < 0.01); and fasting insulin and potassium (P < 0.05). After adjusting for these and other risk factors, SAs demonstrated higher HbA(1c) (6.22 and 6.02%, mean difference 0.20%, 0.10-0.30, P < 0.001), FPG (5.15 and 5.30 mmol/L, mean difference 0.15 mmol/L, 0.09-0.21, P < 0.001), and 2 hrPG (5.82 and 6.57 mmol/L, mean difference 0.75 mmol/L, 0.59-0.92, P < 0.001) compared with WEs, respectively. HbA(1c), FPG, and 2 hrPG levels were higher in SAs independent of factors affecting glycemic control.

  • References13
  • Citations20

Citations

Mentioned in this Paper

Oral Glucose Tolerance Test
European Continental Ancestry Group
Korean Race
Plasma Glucose Measurement
Hb A1a-2
Homeostasis Model Assessment
Potassium supplement
Potassium Measurement
Intravenous Glucose Tolerance Test
Blood Glucose

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