Independent Factors for In-Hospital Death Following Drug-Eluting Stent Thrombosis From the Japanese Adverse Event Report System.

Circulation Journal : Official Journal of the Japanese Circulation Society
Yoshiaki MitsutakeKensuke Ishii

Abstract

Stent thrombosis (ST) is a serious complication after drug-eluting stents (DES) implantation. To identify the risk factors of mortality following ST, we evaluated adverse event reports used for safety measures after approval.Methods and Results:Between July 2004 and August 2019, 2,887 ST case reports were submitted to the Pharmaceutical and Medical Device Agency. Reports of probable or possible ST (n=604), with insufficient data regarding in-hospital outcome or duration between procedure and ST occurrence (n=37) or duplicate reports (n=191) were excluded. Accordingly, 2,045 reports with definite ST were analyzed. Among the subjects, there were 286 in-hospital deaths (14.0%). Multivariate logistic regression analysis revealed that left main trunk (LMT) (odds ratio [OR]: 4.76, 95% confidence interval [CI]: 3.26-6.96), chronic heart failure (CHF) (OR: 2.88, 95% CI: 1.61-5.14), hemodialysis (OR: 2.69, 95% CI: 1.66-4.36), prior stroke (OR: 2.28, 95% CI: 1.15-4.51), over 70 years old (OR: 1.62, 95% CI: 1.22-2.16), and right coronary artery (OR: 0.41, 95% CI: 0.27-0.63) were independent factors for in-hospital death after DES-ST. LMT, CHF, hemodialysis, prior stroke, and older age were independently associated with higher risk of in-h...Continue Reading

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Citations

Aug 4, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Shun Kohsaka
Jan 14, 2021·Cardiovascular Intervention and Therapeutics·Shoichi KuramitsuTakeshi Kimura
May 20, 2021·Circulation Reports·Mitsuhiro TakeuchiTohru Minamino

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