Independent influence of insulin, catecholamines, and thyroid hormones on metabolic syndrome

Obesity
Giovanni De PergolaR Giorgino

Abstract

The objective of this study was to examine whether metabolic syndrome, defined according to adult treatment panel III criteria, is associated with insulin, catecholamines, and thyroid hormones, independently of age and gender. A cohort of 651 euthyroid overweight and obese patients, 440 women and 211 men, aged 18-68 years, were examined. Central fat accumulation (indirectly measured by waist circumference), fasting thyroid-stimulating hormone (TSH), FT(3), FT(4), insulin, glucose, and lipid (cholesterol, HDL-cholesterol, and triglyceride) serum concentrations, 24-h urinary catecholamines, and the level of insulin resistance (estimated by homeostasis model assessment for insulin resistance (HOMA(IR))) were measured. Patients with metabolic syndrome showed higher insulin (P < 0.001) and FT(3) (P < 0.001) serum levels and higher 24-h urinary noradrenaline (P < 0.001) than subjects without this syndrome. The number of metabolic syndrome parameters was directly associated with insulin (P < 0.001) and FT(3) (P < 0.05) serum levels, and with 24-h urinary noradrenaline (P < 0.001) in the whole population. When a multiple regression analysis was performed with the metabolic syndrome as the dependent variable, and age, gender, and insuli...Continue Reading

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Citations

Oct 24, 2012·Journal of Obesity·Giovanni De PergolaFranco Silvestris
Jun 28, 2013·Obesity·Atsushi FujiyaYoji Hamada
Aug 1, 2013·Medical Hypotheses·M G Hristova
Sep 17, 2016·Psychiatric Genetics·Lyndon J ZassStefanie Malan-Müller
May 10, 2017·Thyroid : Official Journal of the American Thyroid Association·Ladan MehranFereidoun Azizi
Apr 1, 2011·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Giovanni De PergolaFranco Silvestris
Aug 3, 2018·Endocrine, Metabolic & Immune Disorders Drug Targets·Luís RaposoAna Cristina Santos
Nov 17, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·Seher KirHulya Coskun
May 28, 2019·Frontiers in Physiology·Martin H LundqvistJan W Eriksson

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