Independent inheritance of genes regulating two subpopulations of mouse clonogenic keratinocyte stem cells

The Journal of Investigative Dermatology. Symposium Proceedings
Natalia V PopovaRebecca J Morris

Abstract

Mouse keratinocyte stem cells originate from the bulge of hair follicle, and, according to definition, possess a clonogenic activity in vitro. We have investigated seven inbred (C57BL/6, C3H, DBA/2, BALB/c, FVB) and outbred (SENCAR, CD-1) mouse strains and found that three genetically distinct subsets of mouse strains differ significantly in the frequency of clonogenic activity in vitro. The analysis of keratinocyte colonies in two reciprocal backcross [C57BL/6 x (BALB/c x C57BL/6); BALB/c x (BALB/c x C57BL/6)] and intercross [(BALB/c x C57BL/ 6)F2] of BALB/c and C57BL/6 mice allowed us to identify two subpopulations of clonogenic keratinocytes able to produce small (less than 2 mm2) and large (more than 2 mm2) colonies. We conducted linkage analysis and found that small colonies associated with mouse chromosomes 1, 6, 7, 8, and 9; but large colonies--with the chromosome 4. We defined locus on the chromosome 9 that associated with small colonies as keratinocyte stem cell locus 1 (Ksc1), and locus on the mouse chromosome 4 associated with large colonies-keratinocyte stem cell locus 2 (Ksc2). Ksc1 and loci on chromosomes 6 and 7 are close if not equal to loci associated with sensitivity to skin carcinogenesis. We conclude that tw...Continue Reading

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Citations

Jan 4, 2012·Photochemistry and Photobiology·Ashok SinghRebecca J Morris
Dec 24, 2010·The Journal of Investigative Dermatology·Thaned Kangsamaksin, Rebecca J Morris
May 16, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Amy PaguiriganCaroline Alexander
Mar 14, 2008·Development, Growth & Differentiation·Kunimasa OhtaHideaki Tanaka
Dec 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Henry K Yip
Jul 9, 2021·Experimental Biology and Medicine·Yu HouYan Zhang

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