Independent predictors of major adverse cardiovascular events in emergency department patients who are hospitalised with a suspected infection: a retrospective cohort study

BMJ Open
Bas de GrootDouwe Rijpsma

Abstract

Emergency department (ED) patients hospitalised with a suspected infection have an increased risk for major adverse cardiovascular events (MACE). This study aims to identify independent predictors of MACE after hospital admission which could be used for identification of high-risk patients who may benefit from preventive strategies. Dutch tertiary care centre and urban hospital. Consecutive, hospitalised, ED patients with a suspected infection. This was a secondary analysis using an existing database in which consecutive, hospitalised, ED patients with a suspected infection were prospectively enrolled. Potential independent predictors, including illness severity, as assessed by the Predisposition, Infection, Response, Organ failure (PIRO) score, and classic cardiac risk factors were analysed by multivariable binary logistic regression. Prognostic and discriminative performance of the model was quantified by the Hosmer-Lemeshow test and receiver operator characteristics with area under the curve (AUC) analyses, respectively. Maximum sensitivity and specificity for identification of MACE were calculated. MACE within 90 days after hospital admission. 36 (2.1%) of the 1728 included patients developed MACE <90 days after ED presenta...Continue Reading

References

Jun 3, 1999·Journal of Accident & Emergency Medicine·M W Cooke, S Jinks
Aug 11, 2000·JAMA : the Journal of the American Medical Association·E M AntmanE Braunwald
Dec 17, 2004·The New England Journal of Medicine·Liam SmeethPatrick Vallance
Dec 6, 2006·Annals of Emergency Medicine·Jin H HanUNKNOWN EMCREG i*trACS Investigators
Jan 16, 2007·Journal of Vascular Surgery·L NorgrenUNKNOWN TASC II Working Group
Jun 7, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julio RamirezJose Bordon
Sep 26, 2009·The Lancet Infectious Diseases·Charlotte Warren-GashAndrew C Hayward
Feb 2, 2010·The Lancet Infectious Diseases·Vicente F Corrales-MedinaDaniel M Musher
Nov 26, 2010·Critical Care Medicine·Michael D HowellNathan I Shapiro
May 7, 2011·Stroke; a Journal of Cerebral Circulation·Mitchell S V ElkindW T Longstreth
Nov 7, 2012·Clinical Biochemistry·Allan S Jaffe
Dec 17, 2014·Critical Care : the Official Journal of the Critical Care Forum·Sanne KuipersOlaf L Cremer
Jan 8, 2015·Journal of the American Heart Association·Marco FalconeFrancesco Violi
Jan 21, 2015·JAMA : the Journal of the American Medical Association·Vicente F Corrales-MedinaSachin Yende

❮ Previous
Next ❯

Citations

Feb 6, 2017·QJM : Monthly Journal of the Association of Physicians·C-A ChengH-W Chiu
Dec 23, 2017·The American Journal of Emergency Medicine·Adrianna LongAlex Koyfman

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.