Abstract
Emergency department (ED) patients hospitalised with a suspected infection have an increased risk for major adverse cardiovascular events (MACE). This study aims to identify independent predictors of MACE after hospital admission which could be used for identification of high-risk patients who may benefit from preventive strategies. Dutch tertiary care centre and urban hospital. Consecutive, hospitalised, ED patients with a suspected infection. This was a secondary analysis using an existing database in which consecutive, hospitalised, ED patients with a suspected infection were prospectively enrolled. Potential independent predictors, including illness severity, as assessed by the Predisposition, Infection, Response, Organ failure (PIRO) score, and classic cardiac risk factors were analysed by multivariable binary logistic regression. Prognostic and discriminative performance of the model was quantified by the Hosmer-Lemeshow test and receiver operator characteristics with area under the curve (AUC) analyses, respectively. Maximum sensitivity and specificity for identification of MACE were calculated. MACE within 90 days after hospital admission. 36 (2.1%) of the 1728 included patients developed MACE <90 days after ED presenta...Continue Reading
References
Aug 1, 1981·Critical Care Medicine·W A KnausD E Lawrence
Jun 3, 1999·Journal of Accident & Emergency Medicine·M W Cooke, S Jinks
Aug 11, 2000·JAMA : the Journal of the American Medical Association·E M AntmanE Braunwald
Mar 11, 2003·Critical Care Medicine·Nathan I ShapiroDavid W Bates
Dec 17, 2004·The New England Journal of Medicine·Liam SmeethPatrick Vallance
May 30, 2006·Lancet·Alan D LopezChristopher J L Murray
Aug 29, 2006·Annals of Emergency Medicine·Maureen ChaseJudd E Hollander
Dec 6, 2006·Annals of Emergency Medicine·Jin H HanUNKNOWN EMCREG i*trACS Investigators
Jan 16, 2007·Journal of Vascular Surgery·L NorgrenUNKNOWN TASC II Working Group
Dec 8, 2007·European Heart Journal·Tim C ClaytonTom W Meade
Jun 7, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julio RamirezJose Bordon
Aug 12, 2008·Resuscitation·Richard BodyKevin Mackway-Jones
Sep 26, 2009·The Lancet Infectious Diseases·Charlotte Warren-GashAndrew C Hayward
Feb 2, 2010·The Lancet Infectious Diseases·Vicente F Corrales-MedinaDaniel M Musher
Nov 26, 2010·Critical Care Medicine·Michael D HowellNathan I Shapiro
May 7, 2011·Stroke; a Journal of Cerebral Circulation·Mitchell S V ElkindW T Longstreth
Nov 7, 2012·Clinical Biochemistry·Allan S Jaffe
Feb 16, 2013·Emergency Medicine Journal : EMJ·Bas de GrootAlice Vis
Mar 4, 2014·PloS One·Jiunn-Tay LeeChung Y Hsu
Nov 16, 2014·BMJ Open·Jacob GamstReimar Wernich Thomsen
Dec 17, 2014·Critical Care : the Official Journal of the Critical Care Forum·Sanne KuipersOlaf L Cremer
Jan 8, 2015·Journal of the American Heart Association·Marco FalconeFrancesco Violi
Jan 21, 2015·JAMA : the Journal of the American Medical Association·Vicente F Corrales-MedinaSachin Yende