Independent prognostic factors in breast cancer patients

American Journal of Surgery
M NaritaM Tsujimoto

Abstract

Recently tumor microvessel density has been shown to be a powerful prognostic tool in breast cancer. We attempted to assess its significance as a prognostic factor. We analyzed the medical records of 100 patients using univariate and multivariate analyses of nine factors as follows; age, tumor size, nodal status, estrogen receptor, C-erbB2, p53, microvessel density, DNA ploidy pattern, and S-phase fraction. Nodal status and microvessel density were independent prognostic indicators for both survival and relapse-free survival. Microvessel density was independent in the node-negative subgroup for survival, but not independent in the node-positive subgroup, while it was independent in both the node-negative and node-positive subgroups for relapse-free survival. Short-term survival rates in the high and low vessel density subgroups were almost the same, and all patients with early death were node-positive. Microvessel density was an important prognostic factor especially in node-negative patients and more significant in long-term survival.

References

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Citations

Mar 10, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A JukkolaG Blanco
Feb 13, 2001·Critical Reviews in Oncology/hematology·G Gasparini
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May 13, 1999·Acta Oto-laryngologica·M BurianC Neuchrist
Dec 8, 1998·International Journal of Cancer. Journal International Du Cancer·P J BostickD S Hoon

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