Independent Prognostic Value of Stroke Volume Index in Patients With Immunoglobulin Light Chain Amyloidosis

Circulation. Cardiovascular Imaging
Paolo MilaniMartha Grogan

Abstract

Heart involvement is the most important prognostic determinant in AL amyloidosis patients. Echocardiography is a cornerstone for the diagnosis and provides important prognostic information. We studied 754 patients with AL amyloidosis who underwent echocardiographic assessment at the Mayo Clinic, including a Doppler-derived measurement of stroke volume (SV) within 30 days of their diagnosis to explore the prognostic role of echocardiographic variables in the context of a well-established soluble cardiac biomarker staging system. Reproducibility of SV, myocardial contraction fraction, and left ventricular strain was assessed in a separate, yet comparable, study cohort of 150 patients from the Pavia Amyloidosis Center. The echocardiographic measures most predictive for overall survival were SV index <33 mL/min, myocardial contraction fraction <34%, and cardiac index <2.4 L/min/m2 with respective hazard ratios (95% confidence intervals) of 2.95 (2.37-3.66), 2.36 (1.96-2.85), and 2.32 (1.91-2.80). For the subset that had left ventricular strain performed, the prognostic cut point was -14% (hazard ratios, 2.70; 95% confidence intervals, 1.84-3.96). Each parameter was independent of systolic blood pressure, Mayo staging system (NT-pro...Continue Reading

References

Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Feb 15, 1986·The American Journal of Cardiology·R B DevereuxN Reichek
May 14, 1998·QJM : Monthly Journal of the Association of Physicians·S W DubreyR H Falk
Aug 14, 1998·Clinical Cardiology·R E McCarthy, E K Kasper
Feb 12, 2002·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Miguel A QuiñonesUNKNOWN Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography
Jul 11, 2002·Journal of the American College of Cardiology·Donald L KingMathew S Maurer
Aug 9, 2003·The New England Journal of Medicine·Giampaolo Merlini, Vittorio Bellotti
Sep 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Angela DispenzieriAllan S Jaffe
Sep 28, 2005·Circulation·Rodney H Falk
Mar 14, 2007·European Journal of Heart Failure·Arnt V KristenThomas J Dengler
Jun 29, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Diego BellaviaFletcher A Miller
Nov 28, 2007·Circulation·Theodore P AbrahamHsin-Yueh Liang
Apr 17, 2010·JACC. Cardiovascular Imaging·Jun Koyama, Rodney H Falk
May 4, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Diego BellaviaFletcher A Miller
Sep 24, 2011·Journal of the American College of Cardiology·John Gorcsan, Hidekazu Tanaka
Feb 15, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shaji KumarMorie A Gertz
Feb 11, 2014·Journal of Hypertension·Stefano PerliniGiampaolo Merlini
Dec 17, 2014·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Amanda TendlerMathew S Maurer
Jan 7, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Roberto M LangJens-Uwe Voigt
Feb 1, 2015·Blood·Carlos Fernández de LarreaGiampaolo Merlini
Jul 30, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Francesca LavatelliGiampaolo Merlini

❮ Previous
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Citations

Aug 31, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sharmila DorbalaJamieson M Bourque
Apr 18, 2020·European Journal of Preventive Cardiology·Alberto AimoMichele Emdin
Jan 17, 2019·European Heart Journal Cardiovascular Imaging·Christina BinderDiana Bonderman
Feb 7, 2019·European Heart Journal Cardiovascular Imaging·Kristina H Haugaa, Øyvind H Lie
Jul 30, 2020·Expert Review of Hematology·Marco BassetGiampaolo Merlini
May 22, 2019·European Heart Journal·Michele EmdinGiampaolo Merlini
May 13, 2018·Circulation. Cardiovascular Imaging·Omar K SiddiqiFrederick L Ruberg
Sep 26, 2020·JACC. Clinical Electrophysiology·Stephanie M KochavMathew S Maurer
Oct 15, 2020·Open Heart·Aénora Roger-RolléUNKNOWN Toulouse Amyloidosis Research Network collaborators
Jan 5, 2021·World Journal of Cardiology·Rafael Vidal-PerezJose Manuel Vazquez-Rodriguez
Oct 15, 2019·JACC. Cardiovascular Imaging·Sharmila DorbalaRodney H Falk
Jun 6, 2021·ESC Heart Failure·Robert Daniel AdamRuxandra Jurcuţ
Aug 18, 2021·European Journal of Preventive Cardiology·Alberto AimoMichele Emdin
Sep 24, 2019·JACC. CardioOncology·Ronald M Witteles, Michaela Liedtke
Sep 1, 2021·Heart Failure Reviews·Tanushree Agrawal, Sherif F Nagueh
Sep 10, 2021·European Heart Journal·Claudio RapezziRita Pavasini

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