Independent validation of DNA-based approaches for age prediction in blood

Forensic Science International. Genetics
Sohee ChoHwan Young Lee

Abstract

Numerous molecular biomarkers have been proposed as predictors of chronological age. Among them, T-cell specific DNA rearrangement and DNA methylation markers have been introduced as forensic age predictors in blood because of their high prediction accuracy. These markers appear highly promising, but for better application to forensic casework sample analysis the proposed markers and genotyping methods must be tested further. In the current study, signal-joint T-cell receptor excision circles (sjTRECs) and DNA methylation markers located in the ELOVL2, C1orf132, TRIM59, KLF14, and FHL2 genes were reanalyzed in 100 Korean blood samples to test their associations with chronological age, using the same analysis platform used in previous reports. Our study replicated the age association test for sjTREC and DNA methylation markers in the 5 genes in an independent validation set of 100 Koreans, and proved that the age predictive performance of the previous models is relatively consistent across different population groups. However, the extent of age association at certain CpG loci was not identical in the Korean and Polish populations; therefore, several age predictive models were retrained with the data obtained here. All of the 3 m...Continue Reading

Citations

May 12, 2018·Electrophoresis·Rebecca RichardsSallyAnn Harbison
Sep 7, 2019·Journal of Forensic Sciences·Helena Correia DiasLicínio Manco
Feb 15, 2020·International Journal of Legal Medicine·Manuel PfeiferMicaela Poetsch
Feb 22, 2018·Aging·Magdalena SpólnickaWojciech Branicki
May 27, 2020·Journal of Forensic Sciences·Alberto MontesantoGiuseppe Passarino
Sep 28, 2017·BMB Reports·Sang-Eun JungHwan Young Lee
Jul 15, 2020·International Journal of Legal Medicine·Barbara Elisabeth KoopStefanie Ritz-Timme
Jan 4, 2020·International Journal of Legal Medicine·Ana Belén Márquez-RuizAurora Valenzuela
Jan 14, 2021·International Journal of Molecular Sciences·Natalia Sławińska, Renata Krupa
Feb 18, 2021·International Journal of Legal Medicine·Nina Sophia MahlkeStefanie Ritz-Timme
Feb 23, 2020·Forensic Science International. Genetics·Hwan Young LeeYang Han Lee
Feb 26, 2021·Electrophoresis·Ting HaoGengqian Zhang
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Chih-Hung LaiZhen Bouman Chen
Apr 2, 2021·Emerging Topics in Life Sciences·Penelope R Haddrill
Jul 11, 2021·International Journal of Legal Medicine·Yessenia AnayaW Reef Hardy
Aug 21, 2021·Aging Cell·Daniel J Simpson, Tamir Chandra
Nov 30, 2018·Analytical Chemistry·Bruce R McCordGeorge Duncan
Nov 6, 2021·International Journal of Legal Medicine·J BeckerS Ritz-Timme

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