Independent validation of the PREDICT breast cancer prognosis prediction tool in 45,789 patients using Scottish Cancer Registry data

British Journal of Cancer
Ewan GraySATURNE Advisory Group

Abstract

PREDICT is a widely used online prognostication and treatment benefit tool for patients with early stage breast cancer. The aim of this study was to conduct an independent validation exercise of the most up-to-date version of the PREDICT algorithm (version 2) using real-world outcomes from the Scottish population of women with breast cancer. Patient data were obtained for all Scottish Cancer Registry (SCR) records with a diagnosis of primary invasive breast cancer diagnosed in the period between January 2001 and December 2015. Prognostic scores were calculated using the PREDICT version 2 algorithm. External validity was assessed by statistical analysis of discrimination and calibration. Discrimination was assessed by area under the receiver-operator curve (AUC). Calibration was assessed by comparing the predicted number of deaths to the observed number of deaths across relevant sub-groups. A total of 45,789 eligible cases were selected from 61,437 individual records. AUC statistics ranged from 0.74 to 0.77. Calibration results showed relatively close agreement between predicted and observed deaths. The 5-year complete follow-up sample reported some overestimation (11.5%), while the 10-year complete follow-up sample displayed mo...Continue Reading

References

Jul 11, 2007·Statistical Methods in Medical Research·Stef van Buuren
Jan 8, 2010·Breast Cancer Research : BCR·Gordon C WishartPaul D P Pharoah
Mar 5, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G C WishartP D P Pharoah
Jan 20, 2016·British Journal of Cancer·N A de GlasJ E A Portielje
May 24, 2017·Breast Cancer Research : BCR·Francisco J Candido Dos ReisPaul D P Pharoah

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Citations

Jan 17, 2021·Cancer Medicine·Karen ZaguirreMasafumi Nakamura
Nov 7, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kimberly H Allison
May 12, 2021·Molecular Diagnosis & Therapy·Benedetta PellegrinoCinzia Solinas
Jan 19, 2022·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea EisenCatherine H Van Poznak

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PREDICT

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